溃疡性结肠炎肠黏膜组织CD8、Fas/FasL和Bcl-2/Bax的表达及关系
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张 姮, 夏 冰, 杨桂芳, 李 瑾
CD8细胞;Fas,FasL;Bcl-2,Bax;溃疡性结肠炎张姮,夏冰,杨桂芳,李瑾.溃疡性结肠炎肠黏膜组织CD8、Fas,FasL和Bcl-2,Bax的表达及关系. 世界华人消化杂志2
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张姮, 武汉市中心医院消化内科 湖北省武汉市 430014
夏冰, 李瑾, 杨桂芳, 武汉大学中南医院内科与病理科, 武汉大学医学院消化系病研究中心、过敏与免疫相关疾病研究中心 湖北省武汉市 430071
张姮, 1997年武汉大学医学院本科毕业, 2004年武汉大学医学院硕士毕业, 现为消化内科主治医师.
通讯作者: 夏冰, 430071, 湖北省武汉市东湖路169号, 武汉大学中南医院内科. bingxia@public.wh.hb.cn
收稿日期: 2005-12-09 接受日期: 2005-12-31
Distribution of CD8 T cells and expression of Fas/FasL and Bcl-2/Bax in ulcerative colitis
Heng Zhang, Bing Xia, Gui-Fang Yang, Jin Li
Heng Zhang, Department of Gastroenterology, Wuhan Central Hospital, Wuhan 430014, Hubei Province, China
Bing Xia, Gui-Fang Yang, Jin Li, Department of Internal Medicine and Pathology, Zhongnan Hospital of Wuhan University; Research Center of Digestive Diseases and Allergic and Immune Diseases, Wuhan University Medical College, Wuhan 430071, Hubei Provine, China
Correspondence to: Dr. Bing Xia, Department of Internal Medicine, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan 430071, Hubei Province, China. bingxia@public.wh.hb.cn
Received: 2005-12-09 Accepted: 2005-12-31
Abstract
AIM:To investigate the expression of Fas/FasL and Bcl-2/Bax and distribution of CD8 T cells as well as their correlations in ulcerative colitis (UC).
METHODS: Immunohistochemistry was used to detect the expression of CD8, Bcl-2/Bax and Fas/FasL in intestinal mucosal tissues from UC (n = 60) and normal controls (n = 60).
RESULTS: The positive rate of CD8 was significantly higher in the epithelia of UC tissues than that in the controls (52% vs 78%, P < 0 ......
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