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纤维连接蛋白检测在肝病中的临床意义
http://www.100md.com 《中国热带医学杂志》 2006年第5期
纤维连接蛋白,,纤维连接蛋白;肝病;肝功能,摘要,关键词,1对象和方法,2结果,3讨论,参考文献
     摘要:目的 探讨纤维连接蛋白(FN)在肝病中的意义。 方法 采用免疫比浊法检测220例各种肝病患者血清FN水平,并与其他肝功能指标进行比较。 结果 急性肝炎与轻/中度慢性肝炎之间差异无显著性(P>0.05);急性肝炎与重度慢性肝炎、肝硬化、慢性重型肝炎之间差异有显著性(P<0.05、P<0.001、P<0.001);与血清白蛋白(ALB)、前白蛋白(PRE-A)、凝血酶原活动度(PTA)呈正相关(P<0.001)。 结论 血清FN水平在一定程度上能反映肝脏损伤的程度,检测血清FN对估计重度慢性肝炎、肝硬化、慢性重型肝炎患者病情、预后、转归均有一定意义。

    关键词:纤维连接蛋白;肝病;肝功能

    Clinical significance of the detection of fibrin in the diagnosis of hepatic illness.

    YANG Xia,XU Ji-tao,JIANG Li-hui,et al.

    (Jilin Municipal Hospital of Infectious Diseases,Jilin132002,Jilin,P.R.China)

    Abstract:Objective To discuss the significance of fibronectin(FN)in liver diseases. Methods FN in220patients with various typs of heptitis were determined with immunoturbidimetry and compared with other indexes of liver function. Results There were no significant differences in the levels of serum FN between acute hepatitis and mild/moderate chronic hepatitis(P>0.05);There were signficant differences in the levels of serum FN between acut hepatitis and severe chronic hepatitis、cirrhosis and chronic severe hepatitis(P<0.05 ......

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