Expressions and correlation of EZH2 and PTEN in prostate cancer

    SONG Li, CUI Xiaoª²Jian, SU Daª²Jun, TAN Guoª²Liang

    Department of Urology, Gong¬ðan Hospital, Tianjin 300045, China

    ¡¾Abstract¡¿ AIM: To investigate the expressions and correlation of EZH2 and PTEN in prostate cancer for the purpose of illusª²trating their relations to pathological grading and clinical phase. METHODS: The expressions of EZH2 and PTEN in 60 cases of prostate cancer were detected with immunohistochemistry of SABC. RESULTS: The expression rates of EZH2 and PTEN were 98.3% and 25.0%. The expressions of EZH2 and PTEN had significant differences in different pathological grading and clinical phases (P<0.05). Meanwhile, we also found there was a negative correlation between EZH2 and PTEN (P<0.05). The expressions of EZH2 and PTEN had no correlation with age, sex, tumor size and location. CONCLUSION: The relation of EZH2 and PTEN may play an important role in the tumorigenesis and tumor progression in prostate cancer. As a testing method, the research can be the index for estimating the level of malignant and progression of the prostate cancer, and expectedly provide some references for diagnosis and treatments. ......