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养阴抗毒胶囊对阴虚大鼠外周血T细胞亚群及IL1β,TNFα的影响
http://www.100md.com 《第四军医大学学报》 2006年第11期
养阴抗毒胶囊;糖皮质激素;阴虚证;T细胞亚群;细胞因子;大鼠,,养阴抗毒胶囊;糖皮质激素;阴虚证;T细胞亚群;细胞因子;大鼠,养阴抗毒胶囊对阴虚大鼠外周血T细胞亚群及IL1β,TNFα的影响
     Effect of Nourishing Yin Antitoxic Capsule on T lymphocyte subsets, IL1β and TNFα of peripheral blood in Yin deficiency rats induced by hydrocortisone

    HOU Ying1, SHI HengJun1, CHEN Ru1, JU Yan1, CAO YunXin2

    1Department of Traditional Chinese Medicine, Tangdu Hospital, Fourth Military Medical University, Xian 710038, China, 2Department of Immunology, School of Basic Medicine, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To explore the effect of Nourishing Yin Antitoxic Capsule (YC) on T lymphocyte subsets and IL1β, TNFα of peripheral blood in Yin deficiency rats induced by hydrocortisone. METHODS: Thirtytwo SD rats were randomly allocated to 4 groups: normal control group, Yin deficiency model control (YD) group, YC group and Liuwei Dihuang Balls (LD) group (with the action of nourishing Yin and replenishing kidney). Radioimmunity method was used to observe the contents of corticosteroid (CORT), IL1β and TNFα in blood serum at 9th day after medicine pretreatment and Yin deficiency model establishment. T lymphocyte subsets of peripheral blood in rats were detected by flow cytometer. RESULTS: Compared with the normal group, the contents of CORT were higher in YD group (P<0.05); and that could be reduced by YC and LD (P<0.05). Meanwhile the contents of IL1β and TNFα were increased significantly in YD group (P<0.05 and P<0.01); and they could be reduced by YC and LD (P<0.05) but ones of YC group approached more to normal control group. The percentages of CD4+ and CD8+ in YD group were increased (P<0.05), the ratio of CD4+/CD8+ was not different significantly between all groups. CONCLUSION: T lymphocyte subsets of peripheral blood are not significantly decreased in Yin deficiency syndrome induced by hydrocortisone. There are correlations between the increased contents of IL1β and TNFα and Yin deficiency syndrome induced by hydrocortisone. YC can decrease the contents of IL1β and TNFα, which might be one of the mechanisms of treating the adverse reaction of glucocorticoids. ......

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