【摘要】 目的 探讨手术后病人血清维生素C含量的变化并为补给适宜剂量的维生素C提供依据。方法 选择54例临床施行中等以上手术病人为观察对象，术前随机分为两组。补给维生素C 500mg/d为观察1组，补给维生素C 1000mg/d为观察2组。两组均为术后当天开始补给，并于术前及手术后3天、7天取清晨空腹血及留24h尿测定维生素C含量。另测94例正常供血者血清维生素C含量为正常值。结果 观察1组病人手术后3天血清维生素C含量恢复至正常水平，7天已超出正常水平高限，24h尿维生素C排出量3天、7天均迅速增加。观察2组病人血清维生素C含量3天、7天均较观察1组病人显著升高。24h尿维生素C排出量术后3天、7天均较观察1组病人明显增加。结论 施行中等以上手术病人补给维生素C 500mg/d是安全，可行的；补给维生素C 1000mg/d是过量的，血清维生素C含量饱和，24h尿排出量明显增加。

     【关键词】 维生素C；供给剂量； 外科病人

    【Abstract】 Objective To study the change in plasma level of vitamin C and its excretion in postoperative patients.Methods The patients were randomized into two groups,500mg/day or 1000mg/day of vitamine C dosage.On preoperative day ,on the 3rd and the 7th postoperative day,the blood samples were obtained.At the same times,the 24hr urine samples were collected to determine the content of vitamin C. 94 blood samples from healthy people were determined as normal value of vitamine C.Results The blood level of vitamine C in surgical patients was increased up to the level of normal persons at the dosage of 500mg/d.When vitamine C was provided in the dosage of 1000mg/d, the patients blood level and the excretion in urine were significantly higher than the normal value.Conclusion It is viable and safe to supply vitamin C in 500mg dose a day to surgical patients, and it is superfluous to supply vitamine C in 1000mg/day. ......