胃窦部幽门螺杆菌清除对萎缩性胃炎病理改变的影响
幽门螺杆菌,,幽门螺杆菌；萎缩性胃炎；病理,1资料与方法,2结果,3讨论,【参考文献】
【摘要】 目的 通过对幽门螺杆菌(Hp)相关的萎缩性胃炎病人Hp清除治疗前后胃窦部黏膜病理改变的分析，来确定Hp对其炎症程度、活动性(中性粒细胞浸润)、腺体萎缩和肠上皮化生的影响。方法 106例Hp相关的萎缩性胃炎患者接受Hp清除治疗，对其治疗前后胃窦部黏膜的病理变化进行分析，分析标准按96悉尼系统评定。结果 在62例治疗成功组中，治疗后胃黏膜的炎症程度及活动性较治疗前明显减轻，但腺体萎缩及肠上皮化生未减轻。在44例治疗失败组中，治疗前后胃黏膜的炎症程度、活动性、腺体萎缩及肠化均没有变化。且随着Hp感染时间的延长，腺体萎缩和肠化还可加重。结论 Hp的清除治疗可使萎缩性胃炎患者胃黏膜的炎症程度及活动度减轻，对此类病人应行Hp清除治疗。【关键词】 幽门螺杆菌；萎缩性胃炎；病理
Influence of Helicobacter pylori eradication treatment on mucosal alteration of atrophic gastritis
GUAN Hong,LIN Boyan,MU Haibin.
The Second Affiliated Hospital of Qiqihar Medical College,Qiqihar 161006,China
【Abstract】 Objective To study the mucosal alterations of patients of Helicobacter pylori(H.pylori)associated atrophic gastritis before and after H.pylori eradication treatment,determine the influence of H.pylori infection on their inflammation,activity,atrophy and intestinal metaplasia.Methods H.pylori eradication treatments were carried on 106 patients of atrophic gastritis,and assess their histopathological feature of gastritis before and after treatment for H.pylori.Histological sections were assessed using 96'Sydney System.Results In the patient group with successful eradication(n=62),there was a marked reduction in inflammation and activity.In contrast,there were no changes in atrophy and intestinal metaplasia in the patient group with eradication failure(n=44),there were no changes in inflammation,activity,atrophy and intestinal metaplasia before and after treatment.What's more,the longer was the time of H.pylori infection,the worse might gland atrophy and intestinal metaplasia be.Conclusion H.pylori eradication treatment can reduce the degree of inflammation and activity.For the patients of atrophic gastritis,it should be carried out. ......
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