前列腺癌内分泌治疗对血PSA的影响及其临床意义
前列腺肿瘤；癌；前列腺特异性抗原,,前列腺肿瘤；癌；前列腺特异性抗原,1资料与方法,2结果,3讨论,【参考文献】
【摘要】 目的 探讨进展期前列腺癌(PCa)患者内分泌治疗前后前列腺特异性抗原(PSA)变化的临床意义。方法 测定PCa患者内分泌治疗前和治疗后3、6、12、24个月血清PSA。结果 治疗后3个月与治疗前相比血清PSA下降明显。治疗后6个月达到PSA谷值。结论 血清PSA可作为判断PCa内分泌治疗效果的标准,血清PSA再次升高(>4ng/ml)提示肿瘤发展为非激素依赖性前列腺癌，是预测生存率的一个独立因素。【关键词】 前列腺肿瘤；癌；前列腺特异性抗原
The significance of the changing of serum PSA after endocrinotherapy in advanced prostatic cancer
ZHU Hongxiang,QIAN Xiongyan,CHEN Shugen,et al.Department of Urology,Luodian Hospital,Shanghai 201908,China
【Abstract】 Objective To detect the changing of the serum PSA in patients with advanced prostatic cancer,and to discuss its significance.Methods A total of 86 consecutive advanced prostate cancer patients treated with antiandrogen medications 24 months after castration were enrolled.Serum levels of prostatic specific antigen(PSA) were obtained just prior to castration,and 3,6,12,24 months after castration.Results 3 months after treatment the serum PSA reduced obviously than it before treatment.6 months after treatment the serum PSA value was in the lowest.Conclusion The serum PSA can be a standard which judge the effect of endocrinotherapy in PCa,and be a very useful prognostic marker.PSA>4ng/ml showed the disease had developed to the hormone refractory PCa. ......
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