高血压；_动脉硬化；_颈动脉；_内皮缩血管肽类；

高血压者颈动脉硬化与血浆内皮素、脂蛋白(a)的关系

http://www.100md.com 《实用老年医学》 2006年第2期

高血压；,动脉硬化；,颈动脉；,内皮缩血管肽类；,脂蛋白,(A)；,老年人,1对象与方法,2结果,3讨论,参考文献

     【摘要】目的探讨老年高血压患者颈动脉病变与血浆内皮素1(ET1)、脂蛋白(a)[Lp(a)]的关系。方法对120例老年高血压患者进行颈动脉超声检查。根据病变的不同分为颈动脉无斑块(NCP)组、硬斑块(HCP)组、软斑块(SCP)组，并测定上述患者ET1，血清Lp(a)的含量。结果颈动脉有斑块(CP)组与NCP组比较，ET1及Lp(a)含量明显增高(P<001) ，SCP组与HCP组比较Lp(a)含量明显增高(P<001)。结论老年高血压患者颈动脉斑块的形成与血管内皮损伤、Lp(a)代谢异常有明显关系。

    【主题词】高血压；动脉硬化；颈动脉；内皮缩血管肽类；脂蛋白 (A)；老年人

    The level of endothelins and lipoprotein(a)[Lp(a)] in elderly hypertensive patients with carotid artery atherosclerotsis LI Hong, PU Jianhong, WANG Fendie. Department of Geriatrics， the First Affiliated Hospital of Suzhou University，Suzhou 215006 China

    【Abstract】 Objective To explore the relationship between endothelins and lipoprotein(a)[Lp(a)] in elderly hypertensive patients with carotid artery atherosclerosis. Methods 120 elderly hypertensive patients were divided into four groups based on the result of carotid artery ultrasonography : nonplaque group (43 cases),hard plaque group (31 cases) and soft plaque group (46 cases). Endothelin1(ET1) and Lp(a) were determined in these patients. Results Compared with nonplaque groups, plaque group had higher levels of ET1 and Lp(a). The difference was significant(P<001)  Compared with hard plaque group,soft plaque group had higher level of Lp(a)(P<001). Conclusions There is a significant association between the formation of carotid atherosclerotic lesions and hypertension injury and disorders of lipids metabolism ......

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