儿童紫癜性肾炎体液免疫状态分析
紫癜性肾炎；体液免疫；免疫球蛋白；补体；发病机制,,紫癜性肾炎；体液免疫；免疫球蛋白；补体；发病机制,【摘要】,【关键词】,1对象与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨紫癜性肾炎患儿的体液免疫状态及其发病机制。 方法 对39例紫癜性肾炎患儿及30例健康儿童的血清采用全自动生化分析仪进行IgG、IgA、IgM、C3、C4检测；紫癜性肾炎患儿另行肾脏病理检查与诊断。比较紫癜性肾炎患儿与健康儿童血清免疫球蛋白及补体的差异性，以及紫癜性肾炎患儿肾脏损害与免疫紊乱的相关性。结果 紫癜性肾炎患儿血清IgG、IgA水平明显高于健康儿童，而IgM、C3、C4低于健康儿童(P<0.05或0.01)。紫癜性肾炎患儿病理级别间血清免疫球蛋白及补体差异均无显著性(P>0.05)。结论 紫癜性肾炎患儿存在严重的免疫功能紊乱，肾脏损害程度似与免疫紊乱无直接相关性。【关键词】 紫癜性肾炎；体液免疫；免疫球蛋白；补体；发病机制
Analyses of humoral immunity state in children with the HenochSchonlein purpura nephritis
Ding Juanjuan，He Qingnan，Zhang Jianjiang，et al
(The Laboratory of Pediatric Nephrology ,the Second Xiangya Hospital, Central South
University, Changsha 410011, China)
【Abstract】 Objective To explore the humoral immunity state and pathogenesis in children with HenochSchonlein purpura nephritis (HSPN). Methods Serum IgG, IgA, IgM, C3 and C4 levels were detected in 39 children with HSPN and 30 healthy ones using fullautomatic biochemistry analyzer. Results Serum IgG and IgA levels of patients were significantly higher, while IgM, C3 and C4 lower compared to controls(P<0.05 or 0.01). There were no significant differences in immunoglobulin and complements as for pathological grades(P>0.05).Conclusion There was severe disturbance of immunologic function in children with HSPN, and degrees of renal damage may not be directly related to immunologic disturbance. ......
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