阿立哌唑治疗首发精神分裂症临床研究
精神分裂症；阿立哌唑；氟哌啶醇；PANSS；TESS,,精神分裂症；阿立哌唑；氟哌啶醇；PANSS；TESS,【摘要】,【关键词】,1对象与方法,2结果,3讨
【摘要】 目的 探讨阿立哌唑对首发精神分裂症的疗效及安全性。方法 将100例首发精神分裂症患者随机分为研究组与对照组各50例，分别给予阿立哌唑和氟哌啶醇治疗，疗程均为6w。于治疗前及治疗第2，4，6w末采用阳性与阴性症状量表、副反应量表评定临床疗效与不良反应。 结果 研究组治疗2、4、6w末阴性症状、反应缺乏、抑郁因子，以及精神症状总体缓解程度与临床治愈率均明显优于对照组(P<0.05或0.01)。治疗6w末研究组有效率90.0%，对照组78.0%。研究组不良反应发生率较对照组低，且程度轻(P<0.05或P<0.01)。结论 阿立哌唑治疗首发精神分裂症，尤其对阴性症状疗效佳，安全性好。【关键词】 精神分裂症；阿立哌唑；氟哌啶醇；PANSS；TESS
Clinical study of aripirazole in the treatment of firstepisode schizophrenia
Yang Jianzhang，Sun Meiling，Meng Yuelan
(Zhumadian Mental Hospital, Zhumadian 463000,Henan,China)
【Abstract】 Objective To explore clinical efficacy and safety of aripirazole in the treatment of firstepisode schizophrenia .Methods 100 firstepisode schizophrenics were randomly divided into research (aripirazole, n=50) and control (haloperidol, n=50)group for 6 weeks. Efficacy and side effects were assessed with the Positive and Negative Symptom Scale(PANSS) and Treatment Emergent Symptom Scale(TESS),before treatment and at the ends of 2nd,4th and 6th week of treatment. Results At the ends of the 2nd,4th and 6th week, remission of negative symptoms, reaction deficiency, depression factor and total mental symptoms as well as clinical cure rate were significantly better in the research than in the control group(P<0.05 or 0.01). At the end of the 6th week, effective rates were 90.0% in the research and 78.0% in the control group respectively. Compared with the control group, incidence of side effects was lower and milder in the research group(P<0.05 or 0.01).Conclusion Aripirazole has better efficacy and safety in the treatment of the firstepisode schizophrenia, especially in negative symptoms. ......
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