【摘要】 目的 在一个较大样本的基础上从孕妇和胎儿两个角度来综合评价经皮附睾穿刺取精术(PESA)结合卵细胞浆内单精子注射技术(ICSI)治疗无精子症的安全性和有效性。方法 将同期因少弱精子症而行ICSI的患者274例共317个促排卵周期设为对照组，试验组为行PESA+ICSI治疗的121例无精子症患者，共行促排卵周期140个。比较两组的妊娠和胎儿出生情况并定期随访出生后后代的发育情况。结果 妊娠率试验组显著高于对照组(51.43% vs 39.43%，P<0.05)，流产率及妊高征发生率两者无明显统计学差异(12.5% vs 11.2%；6.94% vs 9.60%，P>0.05)。胎儿出生体重、性别比及总的畸形发生率两组间差异亦无显著性(P>0.05)。结论 PESA结合ICSI方法并没有增加妊娠分娩并发症及胎儿畸形的发生率，因此是治疗男性无精子症的一种安全、有效的方法。

    【关键词】 经皮附睾穿刺取精术；无精子症；卵细胞浆内单精子注射术；并发症

    Retrospective study about offspring’s safety of ICSI with sperm obtained by PESA for the treatment of azoospermia

    JIN Lei，ZHU Gui-jin，ZHANG Han-wang，et al.

    Reproductive Medicine Center，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China

    【Abstract】 Objective To judge synthesizedly about the safety and effectiveness of intracytoplasmic sperm injection(ICSI) with sperm obtained by percutaneous epididymal sperm aspiration(PESA).Methods The control group was defined as ICSI aiming to treat oligoasthenozoospermia，which included 274 patients totally carrying out 317 hyper-stimulating cycles.The experimental group was 121 patients suffered from azoopermia ......