抑郁症；安神汤；阿米替林；安全性_

解郁泻火安神汤治疗抑郁症疗效观察

http://www.100md.com 《临床心身疾病杂志》 2006年第2期

抑郁症；安神汤；阿米替林；安全性,,抑郁症；安神汤；阿米替林；安全性,【摘要】,【关键词】,1资料与方法,2结果,3讨论,参考文献

     【摘要】 目的探讨解郁泻火安神汤治疗抑郁症的疗效及安全性。方法将60例抑郁症患者随机分为研究组和对照组各30例，研究组应用中药解郁泻火安神汤治疗，对照组应用阿米替林治疗。疗程均为6w。采用汉密顿抑郁量表、药物副作用量表于治疗前及治疗2、4、6w末评定临床疗效和不良反应。结果治疗6w末，两组内治疗前后汉密顿抑郁量表评分差异有极显著性(P<0.01)，两组间同期比较差异无显著性(P>0.05)。研究组显效率77.0%，对照组80%，两组疗效相当(P>0.05)。研究组不良反应程度及发生率明显低于对照组(P<0.01)。结论解郁泻火安神汤治疗痰火郁结型抑郁症与阿米替林疗效相当，安全性、依从性较阿米替林好。

    【关键词】 抑郁症；安神汤；阿米替林；安全性

    Efficacy of depressionrelieving firedraining spiritquieting decoction in depression

    Liang Zhuo, Tian Kewei

    (The 5th People's Hospital of Luoyang,471000, Henan, China)

    【Abstract】 Objective To explore efficacy and safety of depressionrelieving firedraining spiritquieting decoction(DRFDSQD) in depression. Methods 60 patients with depression were randomly divided into research( took the DRFDSQD, n=30) and control( did amitriptyline, n=30) group for 6 weeks. Clinical efficacy and side effects were assessed using the Hamilton Depression Scale(HAMD) and Treatment Emergent Symptom Scale(TESS) before treatment and at the ends of the 2nd, 4th and 6th week of treatment. Results At the end of the 6th week, scores of the HAMD of both groups had the most significant differences from pretreatment(P<0.01) and there was no significant difference between the 2 groups(P>0.05). Effectual rates were 77.0% in the research and 80% in the control respectively, which had no significant difference(P>0.05). Degree and incidence of side effect were significantly lower in the research than in the control(P<0.01). Conclusion The DRFDSQD and amitriptyline have equivalent efficacy in depression, and the has better safety and compliance. ......

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