大鼠肝肠联合移植后肝对小肠的免疫保护作用
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肇 毅, 陆 森, 成 峰, 华一兵, 吴文溪,
模型;大鼠;肝肠联合移植;免疫保护;凋亡,肇毅,华一兵,吴文溪,陆森,成峰,王学浩,肇毅,通讯作者,Immuno-protectiveeffectoflive
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肇毅, 华一兵, 吴文溪, 南京医科大学第一附属医院胃肠外科 江苏省南京市 210029
陆森, 成峰, 王学浩, 南京医科大学第一附属医院肝移植中心 江苏省南京市 210029
肇毅, 2004年南京医科大学博士研究生毕业, 讲师, 主治医师, 主要从事小肠移植和肝小肠联合移植的研究.
通讯作者: 吴文溪, 210029, 江苏省南京市广州路300号, 南京医科大学第一附属医院胃肠外科. wuwenxi99@163.com
电话: 025-83718836-6863
收稿日期: 2006-04-12 接受日期: 2006-05-11
Immuno-protective effect of liver on small bowel in combined transplantation of liver and small bowel
Yi Zhao, Sen Lu, Feng Cheng, Yi-Bing Hua, Wen-Xi Wu, Xue-Hao Wang
Yi Zhao, Yi-Bing Hua, Wen-Xi Wu, Department of Gastrointestinal Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Sen Lu, Feng Cheng, Xue-Hao Wang, Center of Liver Transplantation, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Correspondence to: Dr. Wen-Xi Wu, Department of Gastrointestinal Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. wuwenxi99@163.com
Received: 2006-04-12 Accepted: 2006-05-11
Abstract
AIM: To develop a new combined transplan-tation model of liver and small bowel in rats, and to investigate the protective effect of trans-planted liver on transplanted small bowel.
METHODS: Closed colony Sprague Dawley rats and inbred Wistar rats were included in this study. Five groups were designed: isogene small bowel transplant group (A), isogene liver transplant group (B), xenogene small bowel transplant group (C), xenogene liver transplant group (D), combined transplant of liver and small bowel group (E). Only Wistar rats were used in group A and B, while SD and Wistar rats were used as donors and recipients respectively in group C, D and E. During the combined transplantation of liver and small bowel (CTLS) for the donors, inferior vena cava in chest was cut to construct a muff in the lateral wall of portal vein and cuff was placed ......
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