[摘要]目的：观察碘化N_正丁基氟哌啶醇(F2)对大鼠心肌组织缺血再灌注(I/R)损伤病理改变及早期生长反应蛋白_1(Egr_1)表达变化的影响。方法：制作大鼠I/R损伤模型。常规病理染色技术观察心肌组织形态学变化。免疫组织化学法测定缺血心肌组织Egr_1阳性表达的细胞数。结果：I/R造成大鼠心肌组织病理损伤，尤以炎症反应为重；I/R诱导心肌组织Egr_1表达上调。缺血前给予F2则能减轻I/R所致心肌组织内的各种病理反应，抑制心肌组织内Egr_1的过表达。结论：F2对大鼠I/R心肌组织损伤具有保护作用，这可能与其抑制Egr_1过表达有关。

    [关键词]碘化N_正丁基氟哌啶醇；早期生长反应蛋白_1；心肌；缺血再灌注损伤

    Effects of N_n_butyl Haloperidol Iodide on Myocardial Ischemia/Reperfusion Injury and Egr_1 Expression in Rats

    ZHANG Yan_mei, SHI Gang_gang, HUANG Zhan_qin, GAO Fen_fei, ZHOU Yan_qiong

    (Department of Pharmacology, Shantou University Medical College, Shantou515041, China)

    [Abstract]Objective: To investigate the relationship between the protective effects of N_n_butyl haloperidol iodide(F2)on myocardial ischemia/reperfusion(I/R)injury and the expression of Egr_1. Methods: The rat myocardial I/R models were established. The pathological changes of myocardial tissue were detected by hematoxylin_eosin staining. The early growth response_1(Egr_1)immunopositive cells were counted by immunohistochemistry. Results: I/R caused pathological injury, especially inflammatory response and induced strong expression of Egr_1 in myocardial tissue. F2 significantly attenuated the myocardial injury and inhibited the overexpression of Egr_1 after I/R. Conclusion: F2 can protect myocardiu_m from I/R injury, which might be related to the inhibition of Egr_1 overexpression. ......