关键词 乳腺肿瘤；基因，MDR；肺耐药相关蛋白；预后

    摘要 目的 研究肺耐药相关蛋白(LRP)在乳腺癌组织中的表达，评估其在乳腺癌预后中的作用。方法 采用免疫组织化学方法(IHC)检测60例手术切除的乳腺癌组织中LRP的表达，并分析其与临床、病理特征的关系及对预后的影响。结果 LRP在乳腺癌组织中的阳性表达率为80.0%(48/60)；LRP表达与月经状况、肿瘤大小、腋淋巴结转移、组织分级和激素受体状况均无关(P>0.05)；Kaplan-Meier和Cox多因素分析结果表明LRP虽和无病生存期相关(P<0.05)，但和总生存期却无关(P>0.05)。结论 LRP在乳腺癌组织中具有较高的表达水平，但与乳腺癌患者预后无关。

    PROGNOSTIC SIGNIFICANCE OF LUNG RESISTANCE-ASSOCIATED PROTEIN (LRP) EXPRESSION IN PRIMARY BREAST CARCINOMA

    Wang Shubin,Liu Yajie,Xu Min,et al.

    Department of Oncology,The Second Hospital of Jinan University,Shenzhen 518020,China

    Key words breast carcinoma; gene，MDR; lung resistance-related protein (LRP); prognosis

    Abstract Objective To investigate the relationship between expression of lung resistance-associated protein (LRP) and clinicopathological characteristics and prognosis in primary breast cancer patients. Methods Expression of LRP in 60 breast cancer patients was determined by immunohistochemistry on formalin-fixed ......