血管内皮生长因子·胰腺肿瘤·淋巴_

C和VEGFD蛋白表达在胰腺癌淋巴转移中的意义

http://www.100md.com 《中国普通现代外科进展》 2006年第4期

血管内皮生长因子·胰腺肿瘤·淋巴,,血管内皮生长因子·胰腺肿瘤·淋巴,1资料与方法,2结果,3讨论,参考文献

     【摘要】目的：探讨胰腺癌中VEGFC、VEGFD蛋白表达与淋巴结转移之间的相关关系，阐明癌周淋巴管增生在胰腺癌淋巴转移中的作用及意义。方法：免疫组化检测30例胰腺癌组织中VEGFC、VEGFD的表达及其与临床病理、淋巴结转移的关系。结果：胰腺癌VEGFC、VEGFD蛋白表达阳性率分别为73%(22/30)、57%(17/30)，肿瘤周边部位显著高于肿瘤中心部位，其表达与肿瘤的部位、分化程度、组织学类型无关，与肿瘤的TNM分期有关，Ⅲ~Ⅳ期显著高于Ⅰ~Ⅱ期。在VEGFC、VEGFD蛋白阳性组，淋巴结转移均显著增多。结论：VEGFC和VEGFD与诱导胰腺癌淋巴管生成，促进肿瘤细胞淋巴道转移有关。

    【关键词】血管内皮生长因子·胰腺肿瘤·淋巴

    The significance of VEGFC and VEGFD protein expression in lymphatic metastasis of pancreatic cancer

    HU Anguo1,WANG Dong1,MAO Xinyan1,LI Sheng2,ZHANG Bo2,YI Longhai2

    1Department of General Surgery,The Second Hospital Affiliated to Shandong University of Traditional Chinese Medecine(Jinan 250001,China)

    2Hepatal Biliary Surgery,Shandong Provence Tumor Hospital(Jinan 250117,China)

    【ABSTRACT】Objective:Our aim is to investigate the relationship of VEGFC,VEGFD and lymph node metastasis in pancreatic cancer,and to elucidate the role and significance of the cancerous peripheral lymphatic tissue.Methods: The expression of VEGFC and VEGFD was assayed by means of immunohistochemistry in 30 pancreatic carcinomas.Results:The positive rates of VEGFC、VEGFD were 73% (22/30)、57% (17/30) respectively in pancreatic cancer.The expression of VEGFC、 VEGFD in cancerous invasive edge was significantly higher than that in the center of cancerous tissues.There was no correlation between the expression of VEGFC、VEGFDand the site,differentiation,histology types.Ⅲ~Ⅳ stages of pancreatic cancer showed strong expressions of VEGFC、VEGFD than that Ⅰ~Ⅱ stages of pancreatic cancer.The positive lymph node in positive VEGFC and VEGFD group were higher than that in the negative group.Conclusion:VEGFC and VEGFD induced lymphangiogenisis in pancreatic cancer,promoted the tumor cell lymph metastasis. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/07/13/02/70/25.htm

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