丁螺环酮联合氟西汀治疗强迫症临床观察
氟西汀；丁螺环酮；强迫症；疗效比较,,氟西汀；丁螺环酮；强迫症；疗效比较,【摘要】,【关键词】,1对象与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨丁螺环酮联合氟西汀治疗强迫症的疗效和安全性。 方法 将46例强迫症患者随机分为研究组(氟西汀+丁螺环酮治疗)和对照组(氟西汀治疗)，每组各23例，疗程6w。于治疗前及治疗6w末采用强迫量表、汉密尔顿抑郁、焦虑量表评定临床疗效，副反应量表评定不良反应，并进行对比分析。 结果 治疗6w末研究组显效率89.9℅，对照组显效率60.9℅,强迫量表、汉密尔顿抑郁、焦虑量表评分两组均较疗前明显降低，两组间比较有显著性差异(P<0.05)。 结论 丁螺环酮联合氟西汀治疗，能有效提高对强迫症的治疗效果。【关键词】 氟西汀；丁螺环酮；强迫症；疗效比较
A clinical study of combination of buspirone and fluoxetive in the treatment of obsessivecompulsive disorder
Liu Hua
(The Dongfang people′s hospital of Xuzhou，221004, Jiangsu,China)
【Abstract】 Objective To explore the curative effects and safety of combination of buspirone and fluoxetive in the treatment of obsessivecompulsive disorder(OCD).Metheds 46 patients with OCD were randomly assigned to research group( took buspirone combined with fluoxetive) and control group( single fluoxetive) for 6 weeks. Curative effects were assessed with the YoleBrown ObsessiveCompulsive Scale(YBOCS), Hamilton Depression Scale(HAMD), Hamilton Anxiety Scale(HAMA),and adverse reactions with the Treatment Emergent Symptom Scale(TESS) before treatment and at the end of the 6th week of treatment. Results At the end of 6th week, the effectual rates of research and control groups were 89.9% and 60.9% respectively, scores of the YBOCS, HAMD and HAMA of both the 2 groups significantly decreased, and there were significant differences between the 2 groups(P<0.05). Conclusion Combination of buspirone and fluoxetive has better curative effect in the treatment of OCD ......
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