http://www.100md.com 《临床心身疾病杂志》 2005年第2期
川芎嗪；新生儿；缺氧缺血性脑病；血钙；自由基,,川芎嗪；新生儿；缺氧缺血性脑病；血钙；自由基,【摘要】,【关键词】,1资料与方法,2结果,3讨论,参考文献【摘要】 目的 探讨川芎嗪治疗新生儿缺氧缺血性脑病的疗效和安全性。 方法 将42例缺氧缺血性脑病新生儿随机分为研究组(基本治疗+川芎嗪治疗)23例，对照组(基本治疗)19例，同时选取10例健康儿为健康组。对三组患儿治疗前后一氧化氮、丙二醛、神经元特异性烯醇化酶、血钙、新生儿神经行为量表评分变化进行比较分析。 结果 入院1～2d研究组与对照组血钙无明显差异(t=0.893,P>0.05),且均低于健康组(t=4.866,4.803,P<0.05);10～11d后,治疗组上升明显高于对照组(t=2.341,P<0.05);血浆一氧化氮、丙二醛治疗前研究组与对照组无明显差异,研究组治疗后较治疗前明显下降,与对照组比较差异显著(t=3.76,2.13,P<0.05);研究组与对照组治疗前神经元特异性烯醇化酶无显著差异(t=0.243,P>0.05),两组较健康组高(t=6.09,5077,P<0.01)，研究组治疗后较治疗前显著降低(t=9.15,P<0.01),对照组治疗前与治疗后无显著差异(t=1.839,P>0.05);研究组与对照组治疗前新生儿神经行为量表评分无显著差异, 治疗后研究组较对照组评分差异明显(P<0.05)。 结论 川芎嗪可通过阻止钙内流,减少自由基，对缺氧缺血性脑病新生儿脑组织具有保护作用。
Clinical study on the tetramethylphylpyrazine in the treatment of neonatal hypoxicischemic encephalopathy
Liu Ruifen, Xu Jingxia
(Department of pediatrics, Zhangjiajie people’s hospital, 427000,Hunan,China)
【Abstract】 Objective To explore the curative effects and safety of the tetramethylphylpyrazine(TMPZ) in the treatment of neonates with hypoxicischemic encephalopathy(HIE). Methods 42 neonates with HIE were randomly divided into research group(n=23,basicc treatment combined with TMPZ) and control group(n=19, single basic treatment), and 10 healthy neonates selected as healthy group. Before and after treatment, comparative analyses of nitric oxide(NO), malondialdehyde (MDA), Neuronspecific enolase(NSE),serum calcium and the scores of Neonatal NeuroBehavior Assessment Scale(NNBAS) were conducted among the 3 groups. Results In the 1st and 2nd days of admission, serum calcium of the research and control groups had no difference(P>0.05) and both were lower than the healthy group(P<0.05); after 10~11 days, serum calcium was significantly higher in the research than that in the control group(P<0.05); before treatment there were no obvious differences in plasma NO and MDA between the research group and control group, the NO and MDA of posttreatment were significantly lower than those of pretreatment and had significant difference from the control group(P<0.05); before treatment, the NSE of the research and control groups had no significant difference(P>0.05) and both were higher than the healthy group(P<0.01), that of the research was significantly lower after treatment than before treatment(P<0.01) and that of the control had no obvious difference(P>0.05); the scores of the NNBAS had no obvious difference before treatment and did significant difference after treatment(P<0.05) between the research and control groups. Conclusion The TMPZ can protect brain tissue of neonates with the HIE via preventing serum calcium into cell and decreasing free radical. ......
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