胰岛细胞；肝脏；门静脉；移植；糖尿病_

成人胰岛细胞肝内移植的临床研究(附1例报告)

http://www.100md.com 《东南国防医药》 2005年第3期

胰岛细胞；肝脏；门静脉；移植；糖尿病,,]胰岛细胞；肝脏；门静脉；移植；糖尿病,[摘要],[关键词],1材料与方法,2结果,3讨论,参考文献

     [摘要]目的评估成人胰岛细胞肝内移植治疗1型糖尿病的临床疗效及价值。方法2003年间对1例1型糖尿病患者行了3次成人胰岛细胞肝内移植术，术后观察移植前后的血糖、C肽、胰岛素用量和免疫抑制剂的应用等指标，密切观察病情变化，积极防治并发症。结果移植后患者饮食不受限制，生长发育良好，未发生酮症酸中毒，未发生低血糖反应，血糖平均水平降低了27%，胰岛素用量减少到移植前的40%，C肽水平较移植前有明显的提高。结论建立了成人胰岛细胞肝内移植的一整套方法，取得了治疗1型糖尿病的临床疗效。

     [关键词]胰岛细胞；肝脏；门静脉；移植；糖尿病

    Transplantation of the adult islets of langerhans cells by transportal intrahepar

    GUO Junqi, TAN Jianming, CAI Jinquan,et al.

    Department of Urology,Fuzhou General Hospital of PLA, Fuzhou 350025，Fujian,China

    [Abstract]ObjectiveTo assess the therapeutic effects of transplantation of the adult islet cells by transportal intrahepar for type 1 diabetes.MethodsThree times of intrahepatic transplantation of islet cells were performed in a patient with type 1 diabetes.The changes in blood glucose level , Cpeptide, the dose of insulin and immunologic suppressive drug were observed before and after the transplantation.ResultsAfter the transplantation, the patient's diet was unlimited, she grew normally, the level of blood glucose was decreased to 27% , the dose of insulin was decreased to 40% and the Cpeptide was significantly increased than before. Conclusions The procedure is established for the transplantation of the adult islet cells by transportal intrahepar, there is an affirmative therapeutic effect in the patient with type 1 diabetes after transplantation. ......

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