乳腺肿瘤·受体_雌激素·Ki67·基因(期刊论文)

影响乳腺癌雌激素受体表达的临床病理因素分析

http://www.100md.com 《中国普通现代外科进展》 2006年第4期

乳腺肿瘤·受体,雌激素·Ki67·基因,CerbB2·乏氧诱导因子1α,,乳腺肿瘤·受体，雌激素·Ki67·基因，CerbB2·乏氧诱导因子1α,影响乳腺癌雌激素受体表达的临床病理因

     【摘要】目的：探讨影响乳腺癌雌激素受体(ER)表达的临床病理因素。方法：利用免疫组织化学方法检测76例乳腺癌组织中ER和Ki67、CerbB2及HIF1α的表达，并与临床病理资料进行相关性分析。结果：ER、Ki67、CerbB2及HIF1α在乳腺癌组织中的阳性率分别为67.1%、39.5%、31.6%和54.0%。ER表达与Ki67、CerbB2及HIF1α呈负相关(P<0.05)，与癌组织高分化成正相关(P<0.05)，而与年龄、腋窝淋巴结转移、肿瘤大小及组织学类型无显著相关。结论：乳腺癌组织中Ki67、CerbB2及HIF1α等的高表达可能参与了降低ER表达及原发性内分泌治疗抵抗的发生。

    【关键词】乳腺肿瘤·受体，雌激素·Ki67·基因，CerbB2·乏氧诱导因子1α

    Analysis of clinicopathological factors which influence the expression of estrogen receptor in breast carcinoma

    HAO Jing1,WANG Xiumei1,YI Cuihua1,YU Xuejun1,ZHANG Xin1,HU Dongyan1,LI Ming1,YU Jinming2

    1Cancer Center,Qilu Hospital of Shandong University(Jinan 250012,China)

    2Department of Radiotherapy Shandong Tumor Hospital (Jinan 250117,China)

    【ABSTRACT】Objective:To investigate the clinicopathological parameters which influence the expression of estrogen receptor(ER)in breast carcinomas.Methods:The expression of ER together with progesterone receptor(PR),Ki67,CerbB2 and hypoxia inducible factor1α (HIF1α)were assessed by immunohistochemistry in 76 cases of breast carcinoma,and their correlation with the other clinicopathological factors were also analyzed.Results:ER,Ki67,CerbB2 and HIF1α staining were observed in 67.1%,39.5%,31.6% and 54.0% respectively.ER status was inversely correlated with expression of Ki67,CerbB2 and HIF1α.Besides,ER status had a positive correlation with high differentiation (P<0.05).However,it was not related to any other clinicopathological characteristic,such as age,axillary lymph node metastasis,tumor size and histology.Conclusion:High expression of Ki67,CerbB2 and HIF1αmay play important roles in downregulation of ER and therefore the development of primary endocrine therapy resistance. ......

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