新疆紫草；免疫性肝损伤；保肝作用_

新疆紫草提取物对小鼠免疫性肝损伤的保护作用

http://www.100md.com 《新疆医科大学学报》 2006年第6期

新疆紫草；免疫性肝损伤；保肝作用,,新疆紫草；免疫性肝损伤；保肝作用,摘要,关键词,1材料与方法,2结果,3讨论,参考文献

     摘要：目的：研究新疆紫草提取物AEJI、AEJⅡ对小鼠免疫性肝损伤的保护作用。方法：采用卡介苗(BCG)和脂多糖(LPS)诱导免疫性肝损伤动物模型，观察AEJI、AEJⅡ对小鼠肝脏系数、脾脏系数及血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、肝组织超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSHPx)、丙二醛(MDA)和一氧化氮(NO)水平的影响，并观察肝脏病理组织学变化。结果：AEJI高剂量组和AEJⅡ高、低剂量组均可降低肝脏系数，并使肝组织MDA含量降低(P<0.05或P<0.01)；AEJI高剂量组可降低脾脏系数，并使肝组织SOD活性升高(P<0.05)；AEJ各剂量组均可使肝组织GSHPx活性升高、NO含量降低(P<0.05或P<0.01)；AEJI高剂量组可明显降低小鼠血清ALT、AST的活性(P<0.01或P<0.05)； AEJⅡ高、低剂量组均可明显降低小鼠血清ALT的活性(P<0.05)，AEJⅡ高剂量组可明显降低小鼠血清AST的活性(P<0.05)。 AEJI、AEJⅡ均可不同程度地改善肝脏病理组织性损伤。结论：AEJI和AEJⅡ对小鼠免疫性肝损伤具有保护作用。

     关键词：新疆紫草；免疫性肝损伤；保肝作用

    Protective effects of Arnebia euchroma (Royle) Johnston extracts against the immunological liver injury in mice

    LIU Yan, Maierdan·Mahemuti, Nijiati·Rehemu

    (Department of Pharmaceutics, College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China)

    Abstract: Objective: To study the protective effects of Arnebia euchroma (Royle) Johnston extracts，fatsoluble(AEJI) and water soluble (AEJⅡ) against the immunological liver injury in mice. Methods: The immunological liver injury animal model was established in mice by injection of Bacillus CalmetteGuerin (BCG) and lipopolysaccharide (LPS). The coefficient of liver and spleen; alanine aminotransferase (ALT) and aspartate amiontransferase(AST) activities in serum; superoxide dismutase (SOD) glutathione peroxidase(GSHPx) activities, malondialdehyde (MDA) and nitrous oxide (NO) content in liver homogenate were assayed and hepatic pathological changes were observed. Results: AEJI(0.8 g/kg)and AEJⅡ(2, 4 g/kg)decreased the coefficient of liver and the content of MDA(P<0.05 or P<0.01); AEJI(0.8 g/kg)decreased the coefficient of spleen and increased the activity of liver homogenate SOD(P<0.05); AEJI(0.4, 0.8 g/kg)and AEJⅡ(2, 4 g/kg)increased the activity of liver homogenate GSHPx and decreased the content of NO(P<0.05 or P<0.01); AEJI (0.8 g/kg)decreased the activity of serlum ALT and AST (P<0.01 or P<0.05), AEJⅡ(2, 4 g/kg) decreased the activity of serlum ALT(P<0.05). AEJⅡ(4 g/kg) decreased the activity of serum AST (P<0.05). AEJI and AEJⅡ improved liver histopathology injuries. Conclusions: AEJI and AEJⅡ showed protective effects on the immunological liver injury in mice. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/07/13/02/74/89.htm

您现在查看是摘要页，全文长 9114 字符。