【摘 要】 目的 了解产超广谱β-内酰胺酶(ESBL)菌株在医院的分离、分布的情况，以利于对产ESBL菌株的监控与治疗。 方法 采用Vitek-32全自动细菌仪鉴定和双纸片协同法进行ESBL检测。 结果 我院有22个科室检出ESBL菌株，大肠埃希氏菌及肺炎克雷伯氏菌的ESBL(+)检出率分别达到36.3%和37.7%;目前没有发现对亚胺培南耐药的ESBL菌株。 结论 合理使用及严格限定抗生素的应用指征，对延缓细菌耐药性的产生至关重要。亚胺培南治疗对产ESBL细菌引起的感染效果最好。

    【关键词】 产超广谱β-内酰胺酶;大肠埃希氏菌;肺炎克雷伯氏菌

    The detection of ESBLs and it's clinical significance

    HE Song-bin，LING Yun，YE Chu-yang.

    (Huizhou Central Hospital，Guangdong516001，China)

    【Abstract】 Objective To determine the prevalence of strains producing extended-spectrumβ-lactamase in hospital and to pre-vent the spread of ESBL strains.Methods Strains of ESBL were tested by full-automatic germ instrument and were examined by DDST(double-disk synergy test).Results In our hospital ......