奎硫平；增效剂；难治性强迫症_

奎硫平作为增效剂治疗难治性强迫症疗效观察

http://www.100md.com 《临床心身疾病杂志》 2005年第1期

奎硫平；增效剂；难治性强迫症,,奎硫平；增效剂；难治性强迫症,【摘要】,【关键词】,1对象与方法,2结果,3讨论,参考文献

     【摘要】 目的探讨奎硫平作为增效剂治疗难治性强迫症的疗效。方法对20例难治性强迫症患者在原抗抑郁剂治疗的基础上联合奎硫平治疗，奎硫平起始剂量100mg·d-1，以100mg·1次·2次·w-1逐渐增加剂量，平均日剂量为350.00±131.79mg；疗程8w；采用YaleBrown强迫量表、汉密尔顿焦虑量表、大体评定量表及副反应评定量表分别在治疗前及治疗第8w末各评定1次，并进行对比分析。结果治疗第8w末， YaleBrown强迫量表、汉密尔顿焦虑量表、大体评定量表总分与治疗前比较均有极显性差异(P<0.01)；YaleBrown强迫量表减分率判定：痊愈率10%，有效率65%，无效35%；不良反应程度较轻微，患者均可耐受。结论小剂量奎硫平可作为常规抗抑郁剂的增效剂治疗难治性强迫症。

     【关键词】 奎硫平；增效剂；难治性强迫症

    Curative effects of quetiapine as synergist in the treatment of patients with refractory obsessivecompulsive disorder

    Yang Haichen，Xiong Xuelian，Yu Changhong

    (Shenzhen mental health institute，518020,Guangdong,China)

    【Abstract】 Objective To explore the effects of quetiapine as synergist in the patients with refractory obsessivecompulsive disorder(ROCD). Methods 20 patients with the ROCD were treated with former antidepressants combined with quetiapine, its beginning dosage was 100mg/d and gradually increased, and mean dosage was 350.00±131.79mg/d for 8 weeks. Assessments were conducted and compared by the YaleBrown Obsessive Compulsive Scale(YBOCS), Hamilton Rating Scale for Anxiety(HAMA), Global Assessment Scale(GAS) and Treatment Emergent Symptoms Scale(TESS) before treatment and at the end of the 8th week of the study, respectively. Results At the end of the 8th week of the study, the total scores of the YBOCS, HAMA and GAS had much significant difference compared with pretreatment (P<0.01); according to the scorereducing rate of the YBOCS: recovery rate was 10%, effective 65% and ineffective 35%; side effects were milder and tolerable. Conclusion Small dose quetiapine can be used as synergist of routine antidepressants in the treatment of patients with refractory obsessivecompulsive disorder ......

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