【摘要】 目的 探讨利培酮治疗酒精所致精神障碍的临床疗效及安全性。 方法 将60例酒精所致精神障碍患者随机分为利培酮组和氯丙嗪组，每组各30例，疗程6w。治疗前与治疗第6w末采用阳性与阴性症状量表评定临床疗效，副反应量表评定不良反应。 结果 利培酮组有效率73.3%，氯丙嗪组有效率46.7%，两组差异有显著性(P<0.05)。利培酮组不良反应明显低于氯丙嗪组。 结论 利培酮对酒精所致精神障碍的疗效优于氯丙嗪，且不良反应较少。

    【关键词】 利培酮；氯丙嗪；酒精；精神障碍

    Controlled study of risperidone in mental disorders due to use of alcohol

    Zhang Ziping, Xie Yuanyuan

    (Nanyang mental hospital,473000, Henan, China)

    【Abstract】 Objective To explore efficacy and safety of risperidone in mental disorders due to use of alcohol. Methods 60 patients were randomly divided into risperidone and chlorpromazine group(each n=30) for 6 weeks. Before treatment and in 6th week of treatment, efficacy and side effects were assessed with the Positive and Negative Symptom Scale(PANSS) and Treatment Emergent Symptom Scale(TESS) respectively. Results The effective rates of risperidone and chlorpromazine were respectively 73.3% and 46.7%, difference of the 2 groups was significant(P<0.05).Side effects of risperidone were significantly lower than those of chlorpromazine. Conclusion Risperidone is better than chlorpromazine in the treatment of mental disorders due to use of alcohol and side effects less. ......