甜梦胶囊联合阿普唑仑治疗睡眠障碍对照研究
心身疾病；睡眠障碍；甜梦胶囊；阿普唑仑；联合用药,,心身疾病；睡眠障碍；甜梦胶囊；阿普唑仑；联合用药,【摘要】,【关键词】,1资料与方法,2结果,3讨论
【摘要】 目的 探讨甜梦胶囊联合阿普唑仑治疗睡眠障碍的疗效及不良反应。 方法 将84例睡眠障碍患者按时间顺序分为两组，每组各42例。研究组采用阿普唑仑联合甜梦胶囊治疗，对照组单用阿普唑仑治疗，疗程均为4w。于治疗前和治疗第1、2、4w末及停药后第1、4、8w末采用匹兹堡睡眠质量指数量表评定临床疗效和自行设计的不良反应量表评定不良反应。其中研究组2例不合作、3例失访，资料完整者37例；对照组失访4例，资料完整者38例。两组共65例顺利完成治疗和随访。 结果 经过4w治疗，患者的睡眠质量均得以改善。研究组阿普唑仑的平均剂量低于对照组，且不良反应少而轻，停药后睡眠改善持续时间长。结论 甜梦胶囊联合阿普唑仑治疗失眠症疗效肯定，用药剂量低，且不良反应少而轻，停药后反跳现象不明显。【关键词】 心身疾病；睡眠障碍；甜梦胶囊；阿普唑仑；联合用药
A controlled study of Tianmeng capsule combined with alprazolam in somnipathy
Ding Jiehao, Wang Guoqiang
(Ninxiang county mental hospital,410000, Hunan,China)
【Abstract】 Objective To explore the therapeutic effectiveness and side effects of Tianmeng capsule combined with alprazolam in somnipathy. Methods 84 patients with somnipathy were divided into 2 groups( both n =42) according time order. Research group took Tianmeng capsule combined with alprazolam and control group did single alprazolam for 4 weeks. Clinical effectiveness and side effects were assessed with the Pittsburgh Sleep Quality Index(PSQI) and Selfmade Treatment Emergent Symptom Scale(SMTESS) before treatment and at the ends of 1st,2nd and 4th week during treatment and at the ends of 1st,4th and 8th week after treatment, respectively. 65 patients of both the 2 groups completed treatment and followup. Results After 4 week treatment, sleep quality of the patients improved. Compared with the control group,the mean dosage of alprazolam was smaller in the research group, side effects were fewer and milder and duration of sleep improvement longer after treatment. Conclusion Tianmeng capsule combined with alprazolam had precise curative effect in somnipathy, dose was smaller and side effects were fewer and milder, and rebound phenomenon was not marked after treatment. ......
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