三维适形放射治疗非小细胞肺癌的临床观察
肺肿瘤；,放射疗法；,三维适形放射治疗；,常规放疗；,非小细胞肺癌,,肺肿瘤；,放射疗法；,三维适形放射治疗；,常规放疗；,非小细胞肺癌,摘要,关键词,1
摘要: 目的: 探讨三维适形放射治疗(3DCRT)非小细胞肺癌(NSCLC)的临床近期疗效和毒副反应。 方法: 对三维适形放疗的24例非小细胞肺癌患者(3DCRT组)临床资料进行分析,并与同期行常规放疗(RT)的18例非小细胞肺癌患者(对照组)的疗效和毒副反应进行对比。2组均每周照射5次,每次照射2 Gy。结果: 3DCRT组有效率(CR+PR)为87.5%，常规放疗组为55.5%，两组差异无统计学意义(P>0.05)。两组急性放射性食管炎发生率分别为33.3%和50%；放射性肺炎发生率分别为29.1%和44.4%；白细胞下降发生率分别37.5%和61.1%，两组差异均无统计学意义(P>0.05)。结论： 三维适形放射治疗NSCLC有较好的近期疗效，毒副反应较轻，远期疗效有待进一步观察。关键词: 肺肿瘤； 放射疗法； 三维适形放射治疗； 常规放疗； 非小细胞肺癌
Clinical observation of the three dimensional conformal radiation therapy for non small cell lung cancer
Ayiguli·Kali, ZHANG Jinrong, Palida·Apizi, et al
(Department of Radiation Oncology, Tumor Hospital,Xinjiang Medical University,Urumqi 830011, China)
Abstract: Objective: To evaluate the therapeutic effects and acute side effects of using three dimensional conformal radiotherapy (3DCRT) for non mall cell lung cancer (NSCLC). Methods: Retrospectively analyse the twentyfour patients treated with 3DCRT, Another eightteen pateints were treated with the conventional radiation therapy as the control. All pateints was dilivered at 2 Gy fraction, 5 fraction per week. Results: The overall immediate response rates (CR+PR) of the 3DCRT group and the conventinal radiation group were 87.5% and 55.5% respectively (P>0.05). The acute radiation esophagitis in the 3DCRT group was 33.3% and 50% in the conventional radiation group. The radiation pneumonitis in the 3DCRT group was 29.1% and 44.4% in the conventional radiation group. myelosuppression rates of the 3DCRT group and the conventinal radiation group were 37.5% and 61.1% respectively (P>0.05). Conclusion: The preliminary results of the study shows that 3DCRT was feasible in the treatment of NSCLC with better immediate tumor response and not increase normal tissue complication.However, the effects for a long term survival need futher study. ......
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