固体脂质纳米粒制备方法的研究进展
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魏 静，高子彬，丁平田
(沈阳药科大学 药学院，辽宁 沈阳，110016)
摘要：目的 讨论固体脂质纳米粒的制备方法的研究进展。方法 通过分析、整理和归纳近几年的国内外文献，介绍固体脂质纳米粒的常用的制备方法、载体材料、存在的不足及改进方法。结果与结论 固体脂质纳米粒制备方法多种多样并日趋成熟，所存在的问题已逐渐被解决，该种制剂极具发展前景。
关键词：药剂学；固体脂质纳米粒；制备；研究进展
中图分类号：R944 文献标识码：A
contents
Developments on preparing solid Lipid nanoparticles
WEI Jing, GAO Zi-bin, DING Ping-tian
(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016,China)
Abstract: Objective To review methods for preparing solid lipid nanoparticles (SLNs). Methods According to the recent literatures, the preparation methods were summarized. Furthermore, carriers, existing problems of SLNs and their solutions were included. Result and Conclusion There were various methods for SLNs preparation, among which the high pressure homogenization and microemulsion were used most widely. Several approaches were developed to solve the inherent problems of SLNs which made it a promising dosage form in the pharmaceutical field.
Key words: pharmaceutics; solid lipid nanoparticles; preparation; review
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