【摘要】目的：探讨HBsAg无症状携带者HBVM的转归。方法：对1989年普查发现的135例HBsAg阳性者于1993年及2003年作血清学随访，检测HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc等并作比较分析。 结果：135例HBsAg无症状携带者的总体HBVM感染模式变化不大；小三阳模式相对最为稳定；大三阳中有39.13%转为小二阳，小三阳中有21.28%转为小二阳，小二阳中有28.26%转为小三阳。有23.70%的随访对象曾出现ALT异常升高；主要见于HBeAg阳性者；60岁以上者在10年后的随访中，HBeAg阳性率有增加的趋势。结论：HBsAg无症状携带者的HBVM感染模式总体呈现动态的变化，并有一定的转化规律。

    【关键词 】 乙型肝炎病毒；携带者；血清学；转归

    Analysis on Conversion Pattern of HBV Markers in the Carriers of Hepatitis B Virus

    LU Jian-hua, CHEN Jian-guo, ZHU Yuan-rong, et al

    (Qidong Liver Cancer Institute, Jiangsu 226200 China)

    【Abstract】Objective：To explore the change of conversion of hepatitis B virus markers (HBVM) in the asymptomatic individuals with hepatitis B surface antigen (HBsAg). Methods:Serological follow-up was carried out in 1993 and 2003 for 135 carries that were positive for HBsAg in 1989's screening in Qidong. HBsAg, HBsAb, HBeAg, HBeAb, HBcAb (HBVM 1, 2, 3, 4, and 5) were measured and compared.Results: The change of HBVM infected pattern in the HBsAg carriers was generally not apparent. Pattern of sAg-eAb-cAb (1-4-5) was relatively stable. 39.13% of sAg-eAg-cAb (1-3-5) pattern was converted to sAg-eAb-cAb (1-4-5) pattern, and 28.26% of sAg-cAb (1-5) pattern was converted to sAg-eAb-cAb (1-4-5). 23.70% of the carriers once had abnormal elevated ALT, mostly from the individuals with positive HBeAg. HBeAg seemed have a tendency of increasing for those aged over 60 at time of the 2003's follow-up.Conclusions: The HBVM infected patterns experience dynamic changes, following possible conversion orderliness. ......