利用球面对称设计法筛选泛昔洛韦分散片的优化处方
泛昔洛韦；,分散片；,优化；,球面对称设计,,泛昔洛韦；,分散片；,优化；,球面对称设计,摘要,关键词,1材料,2方法与结果,3讨论,参考文献
摘要：目的：利用球面对称设计法对处方进行优化。方法：以分散均匀性为考察指标，选择影响分散片质量的主要因素进行球面试验，进一步筛选优化处方。结果:按优化处方制备的泛昔洛韦分散片,可在3min内完全崩解。结论：优化处方的泛昔洛韦分散片的体外溶出度明显优于普通片剂。关键词: 泛昔洛韦； 分散片； 优化； 球面对称设计
Optimization of the Formulae of Famciclovir Dispersible Tablet by Spherical Symmetric Design
CHEN hua-tu, LIANG Dong-hong, ZHANG Shao-chun
(The Affiliated Hospital of Guangdong Medical College, Guangdong Zhanjiang 524001, China)
Abstract: Objective: To optimize the formulae by Spherical Symmetric design test. Method: The formulae of Famciclovir dispersible tablet were optimized in terms of disintegrating time by Spherical Symmetric design test. Result: The optimized Famciclovir dispersible tablet disintegrated in 3min. Conclusion: The in-vitro dissolubility of the optimized dispersible tablet is better than that of common tablet.
Key words: Famciclovir; Dispersible tablet; Optimization; Spherical Symmetric design
泛昔洛韦具有广谱抗病毒作用 ......
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