韭菜根液；胃溃疡；超氧化物歧化酶；丙二醛_

韭菜根液对利血平诱发胃溃疡大鼠胃粘膜SOD、MDA的影响

http://www.100md.com 《中华首席医学网》 2006年第3期

韭菜根液；胃溃疡；超氧化物歧化酶；丙二醛,,韭菜根液；胃溃疡；超氧化物歧化酶；丙二醛,1材料与方法,2结果,3讨论,参考文献：

     摘要：目的探讨韭菜根液对利血平诱发大鼠胃粘膜损伤的保护作用及其机制。方法采用肌注利血平制备大鼠胃溃疡模型。大鼠随机分为3组：正常对照组、溃疡模型组、韭菜根液组。检测3组胃粘膜溃疡指数(UI)、SOD活性、MDA含量。结果溃疡模型组大鼠UI值明显增大，SOD活性下降，MDA含量升高；韭菜根液能减轻利血平诱发胃粘膜的损伤，提高SOD活性，降低MDA含量。结论韭菜根液对利血平诱发大鼠胃粘膜损伤有明显的保护作用，其机理可能与其抗脂质过氧化损伤有关。

    关键词：韭菜根液；胃溃疡；超氧化物歧化酶；丙二醛

    Effects of Chives Roots Juice on SOD and

    MDA in Gastric Mucous Membrane of Rats with Stomach

    Ulcer Induced by Reserpine

    HUANG Bilan,YU Liangzhu, LIU Shouxian

    (Department of physiology,Xianning College,Xianning Hubei 437100,China)

    ABSTRACT:Objective To explore the protective mechanism of chives roots juice on gastric mucosa damages induced by reserpine in rats. Methods The stomach ulcer model was established by intramuscular injection reserpion in rats. The rats were randomly divided into three groups：①the normal control group; ②the ulcer model group; ③the chives roots juice group. The ulcer index(UI),superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in gastric mucosa were measured of every group.Results Compared with the normal control group,in model group the UI and MDA level were obviously increased but the SOD activity was decreased.The chives roots juice reduce gastric mucosa injury and MDA content but increase SOD activity.Conclusion Chives roots juice has obviously protective effect on rat with gastric mucosa injury by reserpine.The mechanism is probably related to its antilipid peroxidation actions. ......

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