胃癌组织与血清中VEGF和bFGF的表达意义
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周红凤, 吴 瑾, 王翠华, 张 波, 刘 丹,
胃癌;血管内皮细胞生长因子;碱性成纤维细胞生长因子,周红凤,吴瑾,王翠华,张波,刘丹,王雯,赵宁,周红凤,通讯作者,Expressionofvascula
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周红凤, 吴瑾, 王翠华, 张波, 刘丹, 王雯, 赵宁, 哈尔滨医科大学附属肿瘤医院内科七病房 黑龙江省哈尔滨市 150040
周红凤, 1995年哈尔滨医科大学本科毕业, 2006年哈尔滨医科大学硕士研究生毕业, 主治医师, 主要从事各种肿瘤性疾病的诊断、治疗方面的研究.
黑龙江省教育厅科学技术研究项目, No. 10541145
哈尔滨市科技攻关计划项目, No. 2002AA9CS151-3
通讯作者: 吴瑾, 150040, 黑龙江省哈尔滨市动力区哈平路150号, 哈尔滨医科大学附属肿瘤医院内科七病房.
xianlliu@public.hr.hl.cn
电话: 0451-86298729 传真: 0451-86298730
收稿日期: 2006-04-30 接受日期: 2006-05-22
Expression of vascular endothelial growth factor and basic fibroblast growth factor in gastric carcinoma and their significances
Hong-Feng Zhou, Jin Wu, Cui-Hua Wang, Bo Zhang, Dan Liu, Wen Wang, Ning Zhao
Hong-Feng Zhou, Jin Wu, Cui-Hua Wang, Bo Zhang, Dan Liu, Wen Wang, Ning Zhao,Department of Internal Medicine, the Affiliated Tumor Hospital of Harbin Medical University, Harbin 150040, Heilongjiang Province, China
Supported bythe Science and Technology Research Program from Education Department of Heilongjiang Province, No. 10541145, and the Key Project of Science and Technology of Harbin City, No. 2002AA9CS151-3
Correspondence to: Dr.Jin Wu, Department of Internal Medicine, the Affiliated Tumor Hospital of Harbin Medical University, 150 Haping Road, Dongli District, Harbin 150040, Heilongjiang Province, China. xianlliu@public.hr.hl.cn
Received: 2006-04-30 Accepted:2006-05-22
Abstract
AIM: To investigate the expression of vascular endothelial growth factor (VEGF), basic fibro-blast growth factor (bFGF) in serum and tissues of gastric cancer patients and the clinical charac-teristics of gastric cancer.
METHODS: Avidin-biotin system enzyme-linked immunosorbent assay (ABC-ELISA) was used to examine the serum expression of VEGF and bFGF in preoperative gastric cancer patients (n = 73) and healthy individuals (n = 20). Meanwhile, immunohistochemistry was used to detect the expression of VEGF and bFGF in the cancer and cancer-adjacent tissues ......
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