Comparison of the effect of rocuronium in cardiac patients and nonª²cardiac patients

    DONG Guiª²Xiang

    epartment of Anesthesiology, Second Affiliated Hospital, General Hospital of PLA, Beijing 100091, China

    ¡¾Abstract¡¿ AIM: To observe the neuromuscular and hemodynamic effects of rocuromium. METHODS: Forty patients undergoing elective surgery were divided into 4 groups which received different doses of rocuronium or succinylcholine.Anesthesia was induced with diazepam, etomidate and fentanyl. The neuromuscular blocking and hemodynamic effect, and intubation conditions were compared between cardiac patients and nonª²cardiac patients. RESULTS: The intubation conditions were excellent in all the groups when rocuronium was at 0.7 mg/kg or succinylcholine at 1 mg/kg. Mean onset time was 68 and 74 s (P>0.05) in rocuronium groups. There was no significant difference in clinical duration and recovery index between cardiac and nonª²cadiac disease groups. There were also no clinical significant changes in HR and MAP observed in all the patients after a bolus of rocuroª²nium. CONCLUSION: The hemodynamic effect by 0.7 mg/kg rocuronium (2¡ÁED95) is mild not only in patients without cardiac disease, but also in those with cardiac disease, therefore rocuronium can be used safely both in patients for cardiac and nonª²cardiac surgery. ......