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前列腺癌组织EZH2基因的表达及其意义
http://www.100md.com 《第四军医大学学报》 2006年第13期
前列腺肿瘤;基因;EZH2,,前列腺肿瘤;基因;EZH2,0引言,1对象和方法,2结果,3讨论,【参考文献】
     Expression profile and significance of EZH2 gene in primary prostate cancer

    SONG Li, CUI XiaoJian, SU DaJun, TAN GuoLiang

    Department of Urology, Public Security Hospital of Tianjin City, Tianjin 300045, China

    【Abstract】 AIM: To determine the expression of EZH2 gene in prostate cancer (PCa) and to investigate the relation between EZH2 expression and biological characters of PCa. METHODS: In 40 cases of PCa, 20 cases of benign prostate hyperplasia (BPH), 20 cases of prostatic intraepithelial neoplasia (PIN), the expression of EZH2 was detected by semiquantitative RTPCR and the amplified product was sequenced. RESULTS: All 40 PCa cases were positive in EZH2 expression. There was no expression of EZH2 gene in BPH. Only one of the 20 PIN cases was seen EZH2 expressed positively. EZH2 expression was increased in the advanced compared with the primary PCa (P<0.05), in the lowdifferentiated compared with the highlydifferentiated PCa (P<0.05) and in the hormonedependent compared with the hormoneindependent PCa (P<0.05). However, EZH2 expression did not have a linear correlation with the serum total prostate specific antigen level (P>0.05). CONCLUSION: EZH2 gene plays an important role in the development of prostaic carcinoma. Therefore, the analysis of EZH2 expression will benefit the diagnosis and treatment of prostatic carcinoma. ......

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