冠心病、代谢综合征与慢性肾脏病相关性的临床研究
冠心病；代谢综合征；慢性肾脏病；相关性,,],冠心病；代谢综合征；慢性肾脏病；相关性,1对象与方法,2结果,3讨论,[参考文献]
[摘要] 目的 探讨冠心病(CAD)、代谢综合征(MS)与包括轻度肾损害在内的慢性肾脏病(CKD)的相关性。方法 收集上海长海医院2000年1月～2004年心内科、胸外科符合入选标准的住院733例患者的临床资料进行回顾性分析。按有、无冠心病及是否合并代谢综合征进行分组，分别探讨冠心病、代谢综合征与慢性肾脏损害的关系。统计学方法包括卡方检验、CMH检验和Logistic多因素回归分析。结果 (1)冠心病组慢性肾脏病发病率明显增高，肾功能损害程度与冠脉病变程度显著相关；(2)代谢综合征组慢性肾脏病发病率明显增高；(3)代谢综合征各因子中，高血糖及高血压是慢性肾脏病最重要的危险因素。结论 冠心病与慢性肾脏病显著相关，随着肾功能损害程度地加重，冠心病的危险程度也随之增加；合并代谢综合征组慢性肾脏病患病率明显增高，其中高血糖和高血压是慢性肾脏病的重要影响因子。[关键词] 冠心病；代谢综合征；慢性肾脏病；相关性
Clinical investigation of correlation between metabolic syndrome and chronic kidney disease in coronary heart disease
WU Guangzhe，ZHENG Xing.
Department of Medical Affairs,The 406th Hospital of PLA,Dalian 116041,China
[Abstract] Objective To investigate the relationship between coronary artery disease(CAD,metabolic syndrome(MS)and chronic kidney disease (CKD) including minor renal dysfunction).Methods A retrospective study was performed in 733 patients who had been treated in our Cardiovasology Department and Cardiothoracic Surgery Department in 2000～2004.All patients suspected of coronary artery disease underwent a selective coronary angiography and received a survey of risk factors during the hospitalization. According to the existence of CAD or not, these patients were divided into two groups.The correlation between coronary artery disease and chronic kidney disease was examined.According to the existence of MS or not,these patients were divided into different groups.The relationship between the components of metabolic syndrome and CKD was evaluated. Logistic regression,CMH test and Chisquare test were used in the statistic analysis.Results We observed that significant correlations between the severity of the coronary artery stenosis and levels of chronic kidney disease(γ=0.1911,P<0.001).Metabolic syndrome had higher incidence of chronic kidney disease in patients with coronary artery disease.Logistic regression analysis showed that hyperglycemia,hypertension,obesity,hypercholesterolemia were independent risk factors for chronic kidney disease. Hyperglycemia and hypertension were important risk factors for chronic kidney disease and minor renal dysfunction (plasma glucose OR=35.237, hypertension OR=38.078).Conclusion Significant correlations between the severity of the coronary artery stenosis and levels of renal insufficiency is observed.It is suggested that the development of chronic renal insufficiency increases the risk of coronary artery disease.Metabolic syndrome were significantly correlated with coronary artery disease and chronic kidney disease.The risk increased as a result of a cumulative effect of the components of metabolic syndrome.hyperglycemia and hypertension were important risk factors for chronic kidney disease and minor renal dysfunction. ......
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