同型半胱氨酸对颈动脉粥样硬化的影响及其干预研究
同型半胱氨酸；颈动脉粥样硬化；脑梗死,,],同型半胱氨酸；颈动脉粥样硬化；脑梗死,1对象与方法,2结果,3讨论,[参考文献]
[摘要] 目的 探讨脑梗死患者颈动脉病变与血清同型半胱氨酸(Hcy)水平的关系及叶酸、甲钴胺长期干预对其影响。方法 对165例急性脑梗死患者进行血清Hcy的测定及颈动脉超声检查，并按动脉硬化的程度分组，比较不同程度颈动脉粥样硬化患者Hcy水平，部分高Hcy血症患者给予叶酸、甲钴胺干预，随访2年。结果 随着颈动脉病变程度的加重，血清Hcy浓度呈上升趋势，高Hcy血症干预者动脉内中膜厚度明显减小。结论 高Hcy血症对颈动脉粥样硬化的形成起重要作用，长期给予叶酸、甲钴胺干预可能减轻颈动脉粥样硬化。[关键词] 同型半胱氨酸；颈动脉粥样硬化；脑梗死
Effect of homocystein on carotid artery atherosclerosis and its intervention
WANG Li,XUE Guofang,LI Guanglai,et al.
Department of Neurology,The Second Hospital of Shanxi Medical Univercity,Taiyuan 030001,China
[Abstract] Objective To identify the relationship between serum homocysteine and carotid artery atherosclerosis in patients with cerebral infarction and effects of foliate,methylcobalamin.Methods The concentrations of Hcy were determined by means of fluorescence polarization immunoassay and carotid arteries was examined with color Doppler ultrasound in 165 patients with cerebral infarction.The subjects were divided into 4 groups according to the severity of lesion of carotid artery.The concentrations of Hcy were compared in different groups.The patients with hyperhomocysteinemia received foliate and methylcobalamin.Results When lesion of carotid artery became severer,serum Hcy was higher.The intimamedial thicknesses of carotid artery were significantly decreased in patients with hyperhomocysteinemia who received foliate and methylcobalamin for two years.Conclusion Hyperhomocysteinemia may play an important role in development of carotid artery atherosclerosis.The intervention of foliate and methylcobalamin may reduce carotid artery atherosclerosis. ......
您现在查看是摘要页，全文长 8915 字符。