【摘要】 目的 观察立体定向γ射线放射治疗对直肠癌术后复发的近期疗效和急性放射反应。方法 收集2000年3月～2005年2月收治的经立体定向放射治疗直肠癌术后局部复发病例30例。采用螺旋CT 5mm层厚连续扫描定位，在50%剂量线处给予剂量4～6Gy/次，共治疗12～13次，隔日治疗，3次/周，总剂量52～63Gy(等效总剂量70～84Gy)，分4～5周完成。 结果 随访1年以上，完全缓解率(CR)53.3%, 有效率分别为90%，急性放射损伤(肠炎)发生率为16.7%，1年生存率为76.7%。结论 立体定向放射治疗直肠癌术后复发是一种定位精确，局控率高，并发症少的精确放射治疗技术，是一种安全性高的局部治疗手段。

    【关键词】 癌;直肠;复发/放射疗法;立体定向

    The clinical observation of stereotactic radiotherapy for recurrent rectal carcinoma

    GAO Jian-mei,CHEN Yan,YU Zhi-long.Department of Radiotherapy,The First Affiliated Hospital of Inner Mongolia Medical College,Huhhot 010050,China

    【Abstract】 Objective To evaluate the effect of stereotactic radiotherapy(SRT) in the local control rate and the survival rate of recurrent rectal carcinoma.Methods From March 2000 to February 2005 collected 30 cases of recurrent rectal carcinoma.They were treated with OUR-QGD stereotactic γ-ray therapeutic system under the guide of computer tomography. Each lesion was give a 50% isodose curve coverage PTV and 4～6Gy peripheral dosage per fraction,3 fractions per week with the total dose ranging from 52～63Gy(equivalent total dose 70～84Gy).Results The complete response(CR) and overall response rate were 53.3% 90%, respectively.The 1-year survival rates were 76.7%.The ocurrence rate of the acute radioactive enteritis were 16.7%.The severe acute side effect was not occurred in the course of SRT.Conclusion SRT is a feasible,safe,and effective method for the treatment of local recurrent rectal carcinoma. SRT is able to prolong the survival rates and improve the life quality of patients with recurrent rectal carcinoma.It can increase the local control rate and decrease the incidence of radiation induced normal tissue toxicity within a more short time. ......