慢性乙型肝炎患者肝组织穿孔素表达的临床意义
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王海燕, 贺永文, 朱传武, 钱 峰, 李 明,
肝组织;穿孔素;乙型肝炎,慢性;临床意义,王海燕,朱传武,钱峰,李明,罗湘蓉,常建国,张雪华,贺永文,通讯作者:,电话:, 传真:
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王海燕, 朱传武, 钱峰, 李明, 罗湘蓉, 常建国, 张雪华, 苏州市第五人民医院传染科 江苏省苏州市 215007
贺永文, 华中科技大学同济医学院附属协和医院感染科 湖北省武汉市 430022王海燕, 2003年华中科技大学同济医学院硕士生, 主要从事慢性乙型病毒性肝炎的治疗和免疫学研究.
通讯作者: 朱传武, 215007, 江苏省苏州市, 苏州市第五人民医院传染科. zhuchw@126.com
电话: 0512-65180035 传真: 0512-65291020
收稿日期: 2006-04-28 接受日期: 2006-05-11
Clinical significance of intrahepatic perforin expression in patients with chronic hepatitis B
Hai-Yan Wang, Yong-Wen He, Chuan-Wu Zhu, Feng Qian, Ming Li, Xiang-Rong Luo, Jian-Guo Chang, Xue-Hua Zhang
Hai-Yan Wang, Chuan-Wu Zhu, Feng Qian, Ming Li, Xiang-Rong Luo, Jian-Guo Chang, Xue-Hua Zhang, Department of Infectious Diseases, the Fifth People’s Hospital of Suzhou City, Suzhou 215007, Jiangsu Province, China
Yong-Wen He, Department of Infectious Diseases, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Correspondence to: Chuan-Wu Zhu, Department of Infectious Diseases, the Fifth People’s Hospital of Suzhou City, Suzhou 215007, Jiangsu Province, China. zhuchw@126.com
Received: 2006-04-28 Accepted: 2006-05-11
Abstract
AIM: To investigate the clinical significance of intrahepatic perforin expression in patients with chronic hepatitis B virus (HBV) infection.
METHODS: The hepatic biopsies were performed in 47 patients with chronic hepatitis B, and out of them, 35 patients subsequently received interferon α-2b antiviral therapy. The expression of perforin in liver tissues was detected by immunohistochemistry, and the HBV DNA loads, the serum HBV immunologic markers and transaminases were also determined in peripheral blood samples.
RESULTS: The expression of intrahepatic perforin was positive in 37 patients (13 cases strongly positive). The intensity of perforin showed a significant accordance with serum alanine aminotransferase (ALT) level (χ2 = 8 ......
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