杏仁核外源性胃动素对大鼠胃运动的调节作用及机制
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韩晓华, 徐 珞, 陶尚敏
胃动素;杏仁核;胃运动;迷走神经切断;c-Fos;大鼠韩晓华,徐珞,陶尚敏.杏仁核外源性胃动素对大鼠胃运动的调节作用及机制. 世界华人消化杂志2006;14(22)2159-2163,杏仁
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韩晓华, 陶尚敏, 青岛大学医学院生理教研室 山东省青岛市 266021
徐珞, 青岛大学医学院病理生理教研室 山东省青岛市 266021
韩晓华, 博士, 讲师, 主要从事神经肽结构和功能的研究.
国家自然科学基金资助项目, No. 30470642
通讯作者: 韩晓华, 266021, 山东省青岛市登州路38号, 青岛大学医学院生理教研室. xiaohua.han@163.com
电话: 0532-82991703 传真: 0532-83813986
收稿日期: 2006-06-05 接受日期: 2006-06-14
Effect of exogenous motilin in amygdaloid nucleus on gastric motility and its underlying mechanism in rats
Xiao-Hua Han, Luo Xu, Shang-Min Tao
Xiao-Hua Han, Shang-Min Tao, Department of Physiology, Qingdao University Medical College, Qingdao 266021, Shandong Province, China
Luo Xu,Department of Pathophysiology, Qingdao University Medical College, Qingdao 266021, Shandong Province, China
Supported by National Natural Science Foundation of China, No. 30470642
Correspondence to: Xiao-Hua Han, Department of Physiology, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, Shandong Province, China.xiaohua.han@163.com
Received: 2006-06-05 AccePted: 2006-06-14
Abstract
AIM: To investigate the effect of motilin microinjection into bilateral basomedial amygdaloid nucleus (BMA) on the gastric motility in rats, and explore its underlying mechanism.
METHODS: Forty male Wistar rats were used for four sets of experiments (Exp). Exp 1: Animals received bilateral injections of motilin (MT, 1 mg/side) or normal saline (NS, 0.5 mL/side) into BMA, and both intragastric pressure (IGP) and gastric motility frequency (GMF) were recorded to estimate the gastric motility (n = 14). Exp 2: Pretreatment of vagotomy was carried out in 12 rats, and then MT or NS was injected into BMA as in Exp1. Exp3: Sixty minutes after MT or NS injection into BMA, c-Fos protein expression was detected in the paraventricular nucleus (PVA, n = 7). Exp 4: Motilin contents were measured in five brain areas (hypothalamus, midbrain, pons, medulla, and pituitary gland), using radioimmunoassay (RIA) method (n = 7) ......
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