腹腔注射左旋精氨酸诱导急性坏死性胰腺炎大鼠模型
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赖铭裕, 梁志海, 唐国都, 孙学成
急性坏死性胰腺炎;左旋精氨酸;大鼠模型赖铭裕,梁志海,唐国都,孙学成.腹腔注射左旋精氨酸诱导急性坏死性胰腺炎大鼠模型. 世界华人消化杂志2006;14(22)2233-2236,腹腔注射左
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赖铭裕, 广西医科大学第一附属医院老年消化内科 广西壮族自治区南宁市 530021
梁志海, 唐国都, 广西医科大学第一附属医院消化内科 广西壮族自治区南宁市 530021
孙学成, 温州医学院第一附属医院消化内科 浙江省温州市 325035
广西自然科学基金资助, No. 0447054
通讯作者: 唐国都, 530021, 广西南宁市双拥路6号, 广西医科大学第一附属医院消化内科. tguodu02@yahoo.com.cn
电话: 0771-5356501
收稿日期: 2006-04-17 接受日期: 2006-05-11
L-arginine-induced acute nectotizing pancreatitis by intraperitoneal injection in rats
Ming-Yu Lai, Zhi-Hai Liang, Guo-Du Tang, Xue-Cheng Sun
Ming-Yu Lai, Department of Gerontism Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Zhi-Hai Liang, Guo-Du Tang, Department of Gastroenterology, the First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Xue-Cheng Sun, Department of Gastroenterology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325035, Zhejiang Province, China
Supported by the Natural Science Foundation of Guangxi Zhuang Autonomous Region, China, No. No. 0447054
Correspondence to: Guo-Du Tang, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Province,China. tguodu02@yahoo.com.cn
Received: 2006-04-17 Accepted: 2006-05-11
AbstractAIM: To evaluate the method and mechanism of l-arginine induced acute necrotizing pancreatitis in rats.
METHODS: A total of 60 rats were randomly divided into control group (C, n = 24), acute pancreatitis group (A, n = 36). The rat model of acute necrotizing pancreatitis was induced by intraperitoneal injection of l-arginine (1.0 mg/g, all 3 times) at the concentration of 60 g/L. All the rats were killed at 4th, 12th, 24th and 36th h after modeling. The histopathological scores for pancreas and the level of serum amylase were investigated ......
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