DNA损伤修复基因hOGG1的遗传多态与乙肝相关性HCC的风险
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张 昊, 郝冰涛, 贺福初
肝细胞肝癌;DNA修复基因;遗传多态;HBV感染,张昊,郝冰涛,贺福初,通讯作者,ImpactofDNArepairgenehOGG1S
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张昊, 河南省人民医院老年病研究中心 河南省郑州市 450003
郝冰涛, 贺福初, 军事医学科学院放射医学研究所 北京市 100850
张昊, 2003年郑州大学肿瘤学硕士, 主要从事消化系统肿瘤的诊治工作.
国家863高技术发展项目, No. 2001AA224011
通讯作者: 张昊, 450003, 河南省郑州市, 河南省人民医院老年病研究中心. 0371-zhanghao@vip.163.com
电话: 0371-65580603
收稿日期: 2006-04-26 接受日期: 2006-06-24
Impact of DNA repair gene hOGG1 Ser326Cys polymorphism on the risk of hepatocellular carcinoma
Hao Zhang, Bing-Tao Hao, Fu-Chu He
Hao Zhang,Center of Geriatrics Institute, Henan People’s Provincial Hospital, Zhengzhou 450003, Henan Province, China
Bing-Tao Hao, Fu-Chu He,Institute of Medical Radiology, Academy of Military Medical Sciences, Beijing 100850, China
Supported bythe National High Technology Research and Development Program of China (863 Program), No. 2001AA224011
Correspondence to:Hao Zhang, Center of Geriatrics Institute, Henan People’s Provincial Hospital, Zhengzhou 450003, Henan Province, China. 0371-zhanghao@vip.163.com
Received:2006-04-26 Accepted:2006-06-24
Abstract
AIM: To investigate the associations of suscep-tibility to hepatocellular carcinoma (HCC) with DNA repair gene hOGG1 Ser326Cys polymor-phism.
METHODS: The polymorphism of Ser326Cys in DNA damage repair gene hOGG1 was analyzed by sequencing and genotyping in 96 HCC patients and healthy controls.
RESULTS: The frequencies of Cys/Cys, Cys/Ser and Ser/Ser genotypes were 20.9%, 44.2% and 34.9%, respectively. The odd ratio (OR) of heterozygote Ser/Cys was 1.5, and that of homozygosity Cys/Cys was 1.9, which was significantly higher that of Ser/Ser, respectively. The relative risk of HCC in patients with hepatitis B virus (HBV) infection was over 9 times in patients without HBV infection (OR = 9.2; 95%CI 0.99-5.9). Furthermore, the OR for the variant genotype and HBV infection was 5.5 (95%CI 0.7-240.1) and 10.9 (95%CI1.6-453.3), respectively, while that was 27 ......
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