摘要：目的：调查社区和院内获得性阴沟肠杆菌的临床分布特点和耐药情况。方法：收集五家医院分离63株阴沟肠杆菌采用琼脂纸片扩散法进行药敏试验，用WHONET5软件分析。结果：阴沟肠杆菌感染多见于60岁以上的老年患者，占53.9%，其中肺部感染占85.7%，该菌对三代头孢菌素的耐药率高达44.4～66.7%，其中对头孢唑啉耐药性最高，对环丙沙星和阿米卡星耐药率分别为24.1%和28.6%,而对亚胺培南的敏感性最好。结论：阴沟肠杆菌感染的治疗可根据药敏适用喹诺酮类及氨基糖甙类药物，重症患者可用亚胺培南。

    关键词： 肠杆菌； 阴沟； 抗感染药； 药物耐受性

    Analysis of Clinical Distribution and Drug Resistance of Infection due to Enterobacter Cloacae

    QIU Yun-xia

    (Yishui Central Hospital of Shandong, Shandong Yishui 276400, China)

    Abstract： Objective: To investigate the clinical distribution and the drug resistance of infection due to enterobacter cloacae. Method: 63 strains of enterobacter cloacae were collected from 5 hospitals, A drug sensitive test was performed with kinby-Bauer method and the drug resistance was analysed with WHONET 5. Result: The proportion of patients over 60 years old was 53.9% and the proportion of lung infection was 85.7%. The rate of resistance to third-generation cepholoporins was 44.4%～667%. The rate of resistance to cefazolin was highest, while the rate of susceptibility to imipenem was the highest. The rate of resistance to ciprofloxacin and amikacia were 24.1% and 28.6% respectively. Conclusion: According to the result of drug sensitive test, Quinolone and aminoglycoside may be selected to treat the infections due to enterobacter cloacae, Imipenem may be considered for use in critical patients. ......