美托洛尔针剂在急性心肌梗死的临床应用研究
美托洛尔针剂；急性心肌梗死；心律失常；泵衰竭,,美托洛尔针剂；急性心肌梗死；心律失常；泵衰竭,摘要,关键词,1资料与方法,2结果,3讨论,参考文献
摘要: 目的: 观察静脉注射美托洛尔治疗急性心肌梗死(AMI)的临床疗效及安全性。方法: 34例AMI患者(治疗组)在常规治疗基础上，静脉应用美托洛尔，观察和记录治疗前后心率变化、不良反应及住院期间心脏终点事件，并与40例口服倍他乐克(对照组)进行对照分析。结果: (1) 静脉应用美托洛尔后，急性心肌梗死患者心率能明显降低，平均降低19.4次/ min；(2)早期静脉应用美托洛尔可以有效地预防、治疗房早、室早等心律失常，与对照组相比，差异有统计学意义(P<0.05)；可降低住院期间再梗死、梗塞后心绞痛、死亡等心脏终点事件的发生率。结论: 早期静脉应用美托洛尔安全、有效，可明显改善预后。关键词: 美托洛尔针剂；急性心肌梗死；心律失常；泵衰竭
Study on the application of intravenous metoprolol to patients with acute myocardial infarction
ZHANG Cunxing, Maisumu·Mahemuti
(Department of CCU, Frist Affiliated Hospital, Xinjiang Medical University,Urumqi 830054, China)
Abstract：Objective: To access the clinical effect and safety of intravenous metoprolol therapy in patients with acute myocardial infarction. Methods: On the base of normal treatment, intravenous metoprolol was given in 34 patients with acute myocardial infarction. The heart rates, blood pressure, heart failure syndrome, malignant ventricular arrhythmia and sudden death was observed. These data were compared with 40 patients of AMI without metoprolol injection therapy. Results: The heart rate decreased obviously after intravenous metoprolol was injected, from (103.6±14.5) bpm to (84.2±10.6) bpm； intravenous metoprolol can treat and prevent arrhythmias effectively(P<0.05)； malignant ventricular arrhythmia and sudden death showed statistical differences. Conclusion: Intravenous metoprolol is safe and efficacious in the treatment of the patients with acute myocardial infarction. ......
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