摘要：目的：本文旨在探讨复方枸杞合剂对大鼠、小鼠实验性肝损伤的保护作用。方法：分别以四氯化碳(CCL4)造成大鼠和小鼠急性肝损伤模型，醋氨酚造成小鼠肝坏死模型；用赖氏法测定大鼠和小鼠血清SALT活力、甲醇法测定大鼠血清胆红素含量，并观察醋氨酚中毒对小鼠生存率的影响。结果：复方枸杞合剂能降低大鼠、小鼠SALT水平和胆红素含量，并显著提高醋氨酚中毒的小鼠生存率。结论：复方枸杞合剂对实验性肝损伤具有保护作用。

    关键词： 复方枸杞合剂； SALT； 胆红素； 肝损伤

    A Study of the Protective Effect of Compound Medlar Mixture on Experimental Hepatic Injury

    XING Yan-xia, LI Li-fen, SHAO Hong-e

    (Medical College of Datong University , Shanxi Datong 037008, China)

    Abstract： Objective： To survery the protection of compound medlar mixture against experimental hepatic injury of mouse and rat.Method： Forming an acute hepatic injury model of mouse and rat by using carbon tetrachloride (ccl4) and a hepatic necrosis model of mouse by using acetaminophen(AAP) ,measuring the activity of the serum alanine transaminase(SALT) of mice and rats by Reitman-Frankel’s method, serum bilirubin content of rats by methanol method.The survival rate of mice responsing to AAP poisoning was also observed. Result： Compound medlar mixture can reduce SALT activity and bilirubin content of mice and rats,and can effectively increase the survival rate of mice responsing to AAP poisoning. Conclusion： Compound medlar mixture has an action to protect animal’s hepatic cells from experimental injury. ......