中药调肝理脾方对大鼠乙醇性肝病肝纤维化的影响
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徐光福, 褚月虎, 王晓阳, 田德禄, 王新月,
乙醇性肝病;肝窦毛细血管化;窦周纤维化;调肝理脾方;东宝肝泰片徐光福,褚月虎,王晓阳,田德禄,王新月,李澎涛,杨晋翔,姜良铎.中药调肝理脾方对大鼠乙醇性肝病肝纤维化的影响. 世界华人消化杂
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徐光福, 褚月虎, 王晓阳, 北京中医药大学附属东直门医院感染疾病科 北京市 100700
田德禄, 王新月, 杨晋翔, 姜良铎, 北京中医药大学附属东直门医院消化内科 北京市 100700
李澎涛, 北京中医药大学基础医学院, 北京市 100029
徐光福, 博士, 副主任医师, 副教授, 主要从事中医药治疗慢性肝病、肝纤维化和肝硬化的临床和基础研究.
通讯作者: 徐光福, 100700, 北京市东城区海运仓3号, 北京中医药大学附属东直门医院感染疾病科. guangfuxu@hot.com
电话: 010-84013169
收稿日期: 2006-04-29 接受日期: 2006-06-05
Effect of Tiaogan lipi decoction on alcoholic liver disease in rats
Guang-Fu Xu, Yue-Hu Chu, Xiao-Yang Wang, De-Lu Tian, Xin-Yue Wang, Peng-Tao Li, Jin-Xiang Yang, Liang-Duo Jiang
Guang-Fu Xu, Yue-Hu Chu, Xiao-Yang Wang, Department of Infectious Diseases, the First Affiliated Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100700, China
De-Lu Tian, Xin-Yue Wang, Jin-Xiang Yang, Liang-Duo Jiang, Department of Digestive Diseases, the First Affiliated Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100700, China
Peng-Tao Li, College of Basic Medicine, Beijing University of Traditional Chinese Medicine, Beijing 100029, China
Correspondence to: Guang-Fu Xu, Department of Infectious Diseases, the First Affiliated Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100700, China. guangfuxu@hotmail.com
Received: 2006-04-29Accepted: 2006-06-05
Abstract
AIM: To investigate the effects of Tiangan Lipi decoction (TLD) and Dongbao Gantai tablets (DGT) on the alcoholic liver diseases in rats.
METHODS:The male SD rats in model group were decollated and the livers were harvested after being fed with a mixture of alcohol for 63 d, and the others were randomly divided into natural recovery (NR) group (11 wk), TLD treatment group and DGT treatment group. After lavage treatment for 10 d, all the rats were executed and livers were harvested for observation of pathological changes of hepatocytes, hepatic stellate cells, sinusoidal endothelial cells, sinus, and peri-sinus, respectively, under light and electron microscope, and three kinds of extracellular matrix (ECM) generation were also detected by immunohistochemistry ......
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