不同营养支持途径给予谷氨酰胺对烧伤大鼠肠上皮细胞线粒体呼吸功能的影响
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吕尚军, 彭 曦, 孙 勇, 张 勇, 尤忠义
谷氨酰胺;肠道营养;静脉营养;肠上皮细胞;线粒体;烧伤吕尚军,彭曦,孙勇,张勇,尤忠义.不同营养支持途径给予谷氨酰胺对烧伤大鼠肠上皮细胞线粒体呼吸功能的影响. 世界华人消化杂志2006;1
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吕尚军, 彭曦, 孙勇, 张勇, 尤忠义, 第三军医大学西南医院全军烧伤研究所, 创伤、烧伤与复合伤国家重点实验室 重庆市 400038
吕尚军, 2001年武警医学院学士, 第三军医大学硕士生, 医师, 主要从事烧伤代谢营养的基础研究.
通讯作者: 彭曦, 400038, 重庆市, 第三军医大学西南医院全军烧伤研究所, 创伤、烧伤与复合伤国家重点实验室. pxlrmm@163.com
电话: 023-68754149-8056 传真: 023-65461646
收稿日期: 2006-05-20 接受日期: 2006-06-30
Effects of different nutritional supplements with glutamine on mitochondrial respiratory function of intestinal epithelium in burned rats
Shang-Jun Lv, Xi Peng, Yong Sun, Yong Zhang, Zhong-Yi You
Shang-Jun Lv, Xi Peng, Yong Sun, Yong Zhang, Zhong-Yi You, Institute of Burn Research, Southwest Hospital, the Third Military Medical University; State Key Laboratory of Trauma, Burn and Combined Injury, Chongqing 400038, China
Correspondence to: Dr. Xi Peng, Institute of Burn Research, Southwest Hospital, the Third Military Medical University; State Key Laboratory of Trauma, Burn and Combined Injury, Chongqing 400038, China. pxlrmm@163.com
Received: 2006-05-20Accepted: 2006-06-30
AbstractAIM:To compare the effects of different nutritional supplements with glutamine on the mitochondrial respiratory function of intestinal epithelium in burned rats.
METHODS:One hundred and sixty Wistar rats inflicted with 30% total body surface area (TBSA) full thickness burns were employed as the model and randomly divided into four groups: normal control (C), burned control (B), parenteral nutrition with glutamine (PN+Gln) and enteral nutrition with glutamine (EN+Gln). Isonitrogenously and isocalorically, all the burned rats were supplemented with glutamine or tyrosine at 1.0 g/kg per day, respectively. The following indices including respiratory control rate (RCR), oxygen extraction (Oext), phosphate-to-oxygen (P/O) ratio and intestinal mucosal blood flow (IMBF) were measured at a time table of post burn day (PBD) 1, 3, 5, 7, 10.
RESULTS: After burn injury, ST3 (PBD3: 54 ......
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