c-Fos, c-Jun与Bcl-2蛋白在胃癌组织中的表达及意义
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侯仁好, 初晓艺, 刘希双
凋亡;Fos;Jun;Bcl-2;胃癌;免疫组织化学侯仁好,初晓艺,刘希双.c-Fos,c-Jun与Bcl-2蛋白在胃癌组织中的表达及意义.世界华人消化杂志2006;14(24)2448-2451,c
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侯仁好, 初晓艺, 威海市威海卫人民医院消化科 山东省威海市 264200
刘希双, 青岛大学医学院附属医院内镜诊治中心 山东省青岛市 266003
通讯作者: 刘希双, 266003, 山东省青岛市江苏路16号, 青岛大学医学院附属医院内镜诊治中心. still72@tom.com
电话: 0532-85956961
收稿日期: 2006-03-22 接受日期: 2006-04-16
Expression of c-Fos, c-Jun and Bcl-2 and their significances in gastric carcinoma
Ren-Hao Hou, Xiao-Yi Chu, Xi-Shuang Liu
Ren-Hao Hou, Xiao-Yi Chu, Department of Gastroenterology, Weihaiwei People’s Hospital, Weihai 264200, Shandong Province, China
Xi-Shuang Liu, Center of Endoscopy, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China
Correspondence to: Xi-Shuang Liu, Center of Endoscopy, the Affiliated Hospital of Qingdao University Medical College, 16 Jiangsu Road, Qingdao 266003, Shandong Province, China. still72@tom.com
Received: 2006-03-22Accepted: 2006-04-16
AbstractAIM:To detect the expression of c-Fos, c-Jun and Bcl-2 protein in gastric carcinoma and explore their correlations with the development and biological behavior of gastric carcinoma.
METHODS:SABC immunohistochemistry was used to detect the expressions of c-Fos, c-Jun and Bcl-2 protein in specimens (n = 54) from gastric carcinoma and the corresponding cancer-adjacent tissues. The data were analyzed by Chi-Square test using SPSS software.
RESULTS:The positive rates of c-Fos, c-Jun and Bcl-2 expression were significantly higher in cancer tissues than those in cancer-adjacent ones (68.5% vs 27.8%, c2 = 17.95, P < 0.01; 63.0% vs 24.1%, c2 = 16.61, P < 0.01; 64.8% vs 25.9%, c2 = 16.48, P < 0.01). The significant difference was present in the expression of c-Fos and c-Jun among different histological types (P = 0.018; P = 0.032), but wasn’t among different status of regional lymph node metastasis and TNM stages. Bcl-2 expression was markedly different among different histological types, status of regional lymph node metastasis and TNM stages (P = 0 ......
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