胃腺癌组织P53, P63和P73蛋白表达的意义
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刘 荣, 贺降福, 朱尤庆, 吕永红, 肖绍树
胃癌;P53,P63,P73蛋白;基因;免疫组化,胃腺癌组织P53,P63和P73蛋白表达的意义,刘荣,贺降福,吕永红,肖绍树,朱尤庆,通讯作者:,电话:, 传真:,收稿日期:
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刘荣, 贺降福, 吕永红, 肖绍树, 湖北省黄石市第五人民医院消化内科 湖北省黄石市 435005
朱尤庆, 武汉大学中南医院消化内科 湖北省武汉市430071
通讯作者: 刘荣, 435005, 湖北省黄石市下陆大道98号, 黄石市五医院消化内科. rongL66@yahoo.com.cn
电话: 0714-5321186 传真:0714-5328212
收稿日期: 2006-06-05 接受日期: 2006-07-10
Expression of P53, P63 and P73 protein and their significances in gastric adenocarcinoma
Rong Liu, Jiang-Fu He, You-Qing Zhu, Yong-Hong Lv, Shao-Shu Xiao
Rong Liu, Jiang-Fu He, Yong-Hong Lv, Shao-Shu Xiao, Department of Gastroenterology, the Fifth People’s Hospital of Huangshi City, Huangshi 435005, Hubei Province, China
You-Qing Zhu, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan430071, Hubei Province, China
Correspondence to: Rong Liu, Department of Gastroenterology, the Fifth People’s Hospital of Huangshi City, 98 Xialu Street, Huangshi 435005, Hubei Province, China. rongL66@yahoo.com.cn
Received: 2006-06-05 Accepted: 2006-07-10
AbstractAIM:To explore the relationships between the expressions of P53, P63 and P73 protein and the carcinogenesis of gastric adenocarcinoma (GAC).
METHODS:Immunohistochemistry method was used to detect the expressions of P53, P63 and P73 proteins in tissues from 72 GACs and adjacent normal tissues.
RESULTS:The positive rates of P53, P63 and P73 expression in GAC were significantly higher than those in the normal tissues (c2 = 4.72, P < 0.05; c2 = 5.51, P < 0.05; c2 = 9.75, P < 0.01). The expression of P53 protein was distinctly higher in GAC of diffuse type than that in GAC of intestinal type (c2 = 4.68, P < 0.05), and marked differences were observed between lowly-differentiated GAC and highly-, moderately-differentiated GAC (c2 = 7.06, P < 0.05) as well as between GAC of stage Ⅰ,Ⅱand stage Ⅲ,Ⅳ (c2= 3.95, P < 0.05). There was significant difference for P63 expression between lowly-differentiated GAC and highly-, moderately-differentiated GAC (c2 = 7 ......
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