西咪替丁治疗大鼠非乙醇性脂肪性肝炎
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闻勤生, 徐 辉, 王旭霞, 常 青, 张亚飞,
西咪替丁;非乙醇性脂肪性肝炎;细胞色素P450;透明质酸闻勤生,徐辉,王旭霞,常青,张亚飞,李军.西咪替丁治疗大鼠非乙醇性脂肪性肝炎. 世界华人消化杂志2006;14(24)2377-23
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闻勤生, 徐辉, 王旭霞, 第四军医大学唐都医院消化内科 陕西省西安市 710038
常青, 中国人民解放军301医院干部病房 北京市 100078
张亚飞, 李军, 第四军医大学唐都医院传染科 陕西省西安市 710038
闻勤生, 第四军医大学唐都医院消化内科教授、主任医师、医学博士, 主要从事消化内科临床与实验研究.
陕西省自然科学研究计划项目资助, No. 2003C2035
通讯作者: 闻勤生, 710038, 陕西省西安市新寺路1号, 第四军医大学唐都医院消化内科. gastdyy9@fmmu.edu.cn
电话: 029-84777421 传真: 029-84777597
收稿日期: 2006-06-06 接受日期: 2006-06-14
Experimental study on cimetidine in treatment of nonalcoholic steatohepatitis in rats
Qin-Sheng Wen, Hui Xu, Xu-Xia Wang, Qing Chang, Ya-Fei Zhang, Jun Li
Qin-Sheng Wen, Hui Xu, Xu-Xia Wang, Department of Gastroenterology, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038, Shaanxi Province, China
Qing Chang, the 301st Hospital of Chinese PLA, Beijing 100078, China
Ya-Fei Zhang, Jun Li, Department of Infectious Diseases, Tangdu Hospital, the Fourth Military Medical University, Xi’ an 710038, Shaanxi Province, ChinaSupported by Natural Science Research Program of Shaanxi Province, No. 2003C2035
Correspondence to: Dr. Qin-Sheng Wen, Department of Gastroenterology, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038, Shaanxi Province, China. gastdyy9@fmmu.edu.cn
Received: 2006-06-06 Accepted: 2006-06-14
Abstract
AIM: To investigate the efficacy and mechanism of cimetidine in the treatment of rat nonalcoholic steatohepatitis (NASH).
METHODS: Thirty male Sprague Dawley rats were randomly and averagely divided into group A, B and C. High-fat diet was given to the rats in group A and B to induce NASH model, and those in group C served as normal controls. Moreover, the rats in group B were intragastrically treated with cimetidine (200 mg/d) for 12 wk. The levels of cytochrome P450 (CYP450), CYP2E1 and the damages of liver tissues, as well as the level changes of alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood glucose, insulin, and hyaluronic acid (HA) were measured ......
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