SKP2在大肠癌组织中的表达及预后意义
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孙立春, 隋广杰, 刘亚琴
S期激酶相关蛋白2;大肠癌;预后,孙立春,隋广杰,刘亚琴,孙立春,通讯作者,ExpressionandprognosticsignificanceofS-pha
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孙立春, 隋广杰, 刘亚琴, 哈尔滨医科大学附属肿瘤医院内四科 黑龙江省哈尔滨市 150040
孙立春, 2005年哈尔滨医科大学肿瘤学博士毕业, 哈尔滨医科大学附属肿瘤医院内四科主治医师, 主要从事肿瘤化疗和基因治疗的研究.
哈尔滨市科技攻关资助项目, No. 2004AA9CS196-10
通讯作者: 孙立春, 150040, 黑龙江省哈尔滨市哈平路150号, 哈尔滨医科大学附属肿瘤医院内四科. sunlichun114@163.com
电话: 0451-86822727
收稿日期: 2006-06-29 接受日期: 2006-07-19
Expression and prognostic significance of S-phase kinass-associated protein 2 in colorectal carcinoma tissues
Li-Chun Sun, Guang-Jie Sui, Ya-Qin Liu
Li-Chun Sun, Guang-Jie Sui, Ya-Qin Liu,the Forth Department of Internal Medicine, the Affiliated Tumor Hospital of Harbin Medical University, Harbin 150040, Heilongjiang Province, China
Supported bythe Key Science Research Project of Harbin Municipality, No. 2004AA9CS196-10
Correspondence to:Li-Chun Sun, the Forth Department of Internal Medicine, the Affiliated Tumor Hospital of Harbin Medical University, 150 Haping Road, Harbin 150040, Heilongjiang Province, China. sunlichun114@163.com
Received:2006-06-29 Accepted:2006-07-19
Abstract
AIM: To detect the expression of S-phase kinase associated protein 2 (SKP2) and assess its prognostic value in human colorectal carcinoma.
METHODS: SP immunohistochemical method was used to detect the expression of SKP2 P27 proteins in the tissues of colorectal carcinoma (n= 68). Survival analyses were performed using the Kaplan-Meier method and Cox regression model.
RESULTS: Of 68 cases with colorectal carcinoma, the positive rates of SKP2 and P27 expression were 41.2% (n = 28) and 52.9% (n = 36). The expression of SKP2 was significantly correlated with the differentiation of carcinoma (χ2 = 14.073, P = 0.001), but it had no significant correlation with tumor AJCC staging, the gender and ages of patients (P > 0.05). There was a negative correlation between SKP2 and P27 expression (r = -0.528, P = 0.0001). With regard to prognosis, the overall survival rate for patients with the high-SKP2 expression was significantly lower as compared with that for the ones with low-SKP2 expression (31 ......
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