Clara细胞分泌蛋白；肺功能；哮喘；儿童_

哮喘儿童Clara细胞分泌蛋白与肺功能的相关性及临床意义

http://www.100md.com 《第四军医大学学报》 2006年第16期

Clara细胞分泌蛋白；肺功能；哮喘；儿童,,Clara细胞分泌蛋白；肺功能；哮喘；儿童,0引言,1对象与方法,2结果,3讨论,【参考文

     Relationship between Clara cell secretory protein levels and lung function in asthmatic children

    WEN ZhiHong, XIE QingLing, HU QiongYan, DU Hua

    Department of Paediatrics,Peoples Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China

    【Abstract】 AIM: To evaluate the clinical significances of Clara cell secretory protein (CCSP), and the correlation between CCSP levels and lung function in children with asthma. METHODS: Sera were collected from 29 cases during asthmatic attacks, among them 16 asthmatic children being in stable conditions after treatment, and 20 healthy children as controls. Serum CCSP concentrations were measured by a human CCSP enzymelinked immunosorbent assay (ELISA). Lung function was monitored in children with asthma. RESULTS: Asthmatic children appeared significantly lower levels of CCSP in sera during asthmatic attacks [(5.49±2.52) μg/L] or in stable conditions[(9.25±3.38) μg/L] as compared to healthy ones [(12.31±3.90) μg/L, P<0.001], espically those in acute asthma. Furthermore, there was a strongly positive correlation between serum CCSP and FEV1, FEV1/FVC, FEF25, FEF50, FEF75, PEFR in asthmatic children.CONCLUSION: CCSP may play a role in controlling inflammation in the airway and protecting the pulmonary function in chronic asthma. ......

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